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Cannabinoid

CBD for Cannabis

Phase 1
Waitlist Available
Led By Tory Spindle, PhD
Research Sponsored by Johns Hopkins University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up days 1, 2, 3, 7, 10, and 17
Awards & highlights

Study Summary

This trial will study the effects of CBD topical products containing low levels of THC.

Eligible Conditions
  • Cannabis
  • Drug Effects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~days 1, 2, 3, 7, 10, and 17
This trial's timeline: 3 weeks for screening, Varies for treatment, and days 1, 2, 3, 7, 10, and 17 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Blood cannabinoids
Change in Urine cannabinoids
Secondary outcome measures
Change in Cognitive performance as assessed by the Divided Attention Task
Change in Hair cannabinoids
Change in Oral fluid cannabinoids
+3 more

Side effects data

From 2014 Phase 2 trial • 50 Patients • NCT01844687
2%
headache
2%
Blurred Vision
2%
Cold Symptoms
2%
Gastrointestinal Upset
2%
anxiety
100%
80%
60%
40%
20%
0%
Study treatment Arm
Active MJ With 0 mg CBD
Active MJ With 200 mg CBD
Active MJ With 400 mg CBD
Active MJ With 800 mg CBD
Inactive MJ With 0 mg CBD
Inactive MJ With 200 mg CBD
Inactive MJ With 400 mg CBD
Inactive MJ With 800 mg CBD

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Topical CBD Product with low level of THCExperimental Treatment2 Interventions
Participants will topically apply a high CBD-product that also contains low levels of THC.
Group II: Placebo topical productPlacebo Group1 Intervention
Participants will topically apply a placebo product that does not contain cannabinoids.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
CBD
2016
Completed Phase 2
~460
THC
2017
Completed Phase 1
~330

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Substance Abuse and Mental Health Services Administration (SAMHSA)FED
30 Previous Clinical Trials
23,261 Total Patients Enrolled
2 Trials studying Cannabis
69 Patients Enrolled for Cannabis
Johns Hopkins UniversityLead Sponsor
2,262 Previous Clinical Trials
14,823,117 Total Patients Enrolled
7 Trials studying Cannabis
194 Patients Enrolled for Cannabis
Tory Spindle, PhDPrincipal InvestigatorJohns Hopkins University
5 Previous Clinical Trials
337 Total Patients Enrolled
1 Trials studying Cannabis
21 Patients Enrolled for Cannabis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What therapeutic applications has cannabidiol been used for?

"CBD has been demonstrated to be effective in treating those who suffer from inadequate response to conventional therapy, multiple sclerosis, and pharmacotherapy."

Answered by AI

How might the use of CBD pose a risk to individuals seeking treatment?

"Given the Phase 1 status of this trial, there is limited data on CBD's safety and efficacy; therefore, our team at Power gives it a score of 1."

Answered by AI

Can seniors aged 85 and above partake in this clinical investigation?

"Patients aged 18 - 55 are eligible to enrol in this trial. There is a separate 36-trial study for minors and another 144-trial program open to older adults."

Answered by AI

What is the uppermost limit of participants for this exploration?

"Affirmative. According to clinicaltrials.gov, this research project is still recruiting patients since it was first posted on July 14th 2021 and recently updated on July 5th 2022. The trial aims to include 200 participants from a single site."

Answered by AI

Which types of individuals could benefit from participation in this research program?

"This research is seeking 200 individuals with cannabis dependency aged between 18 and 55. Key criteria for participants include: having a SBP of 150 mmHg or lower and DBP of 90mmHg or less, presenting written informed consent, being within the specified age range, displaying general health based on physical examination, medical history, vitals signs and drug-screening tests (urine/blood), testing negative in recent urine screenings for marijuana use as well as other recreational substances including alcohol upon both screening visit and experimental session arrivals; if female – not pregnant nor nursing (with appropriate pregnancy test results at each study visit); BMI ranging 19"

Answered by AI

What are the overarching aims of this trial?

"This clinical trial is aimed at gauging the Change in Blood cannabinoids over a 1, 2, 3, 7, 10 and 17 day period. Secondary objectives entail determining any shifts in Cognitive performance (measured as mean cursor distance from central stimulus with Divided Attention Task), Psychomotor performance (quantified by number of correct trials within 90 seconds on Digit Symbol Substitution Test) and Subjective drug effects (assessed via Drug Effect Questionnaire ranging 0-100)."

Answered by AI

Are there existing investigations of cannabidiol's efficacy?

"Currently, 104 clinical research projects regarding Cannabidiol (CBD) are being conducted. 19 of these active studies have progressed to Phase 3. 331 sites across the United States are running trials for this potential therapy, with Belmont Massachusetts having a particularly high concentration of such studies."

Answered by AI

Is this research taking on new participants?

"As per the clinicaltrials.gov listing, this trial is currently accepting enrollees. The study was initially posted on July 14th 2021 and has been revised most recently on July 5th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Maryland
How old are they?
18 - 65
What site did they apply to?
Johns Hopkins Behavioral Pharmacology Research Unit
What portion of applicants met pre-screening criteria?
Met criteria
~13 spots leftby Apr 2025