Lysine Chloride for Heart Failure

Phase-Based Progress Estimates
Yale University, New Haven, CTHeart FailureLysine Chloride - Drug
All Sexes
What conditions do you have?

Study Summary

This trial is studying whether adding chloride to diuretic therapy may improve heart failure symptoms in patients who are volume-overloaded.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Daily for 7 days

Daily for 7 days
Change in Blood Volume
Daily for 7-days
Change in Bicarbonate
Change in Chloride
Change in Cystatin C
Change in Serum Creatinine
Change in log NTpro-BNP

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Lysine Chloride
1 of 2
1 of 2

Experimental Treatment

Non-Treatment Group

125 Total Participants · 2 Treatment Groups

Primary Treatment: Lysine Chloride · Has Placebo Group · Phase < 1

Lysine Chloride
Experimental Group · 1 Intervention: Lysine Chloride · Intervention Types: Drug
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Other
First Studied
Drug Approval Stage
How many patients have taken this drug
Chloride ion
Not yet FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: daily for 7 days

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,703 Previous Clinical Trials
20,475,804 Total Patients Enrolled
29 Trials studying Heart Failure
54,454 Patients Enrolled for Heart Failure
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,617 Previous Clinical Trials
47,118,229 Total Patients Enrolled
196 Trials studying Heart Failure
673,309 Patients Enrolled for Heart Failure

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You are taking loop diuretics for a long time.

Frequently Asked Questions

Are there any vacancies for prospective participants in this experiment?

"According to the data presented on, this investigation into a novel medical treatment is still seeking participants and has been updated recently - July 12th 2018 being the initial post date and July 20th 2022 being most recent change." - Anonymous Online Contributor

Unverified Answer

What health conditions is Lysine Chloride commonly utilized to address?

"Lysine Chloride is usually utilized to supplement dietary amino acid levels. Additionally, it can be effective at treating symptoms of anorexia nervosa such as loss of appetite and poor diet intake." - Anonymous Online Contributor

Unverified Answer

How many people are participating in the current clinical experiment?

"Affirmative, the information published on shows that this trial is currently open for recruitment. It was first posted on July 12th 2018 and most recently updated early last month (July 20th 2022). This research endeavour needs to find 125 participants at a single medical site." - Anonymous Online Contributor

Unverified Answer

To what extent has Lysine Chloride been explored in other scientific investigations?

"Presently, there are 99 active clinical trials for Lysine Chloride with 36 of those studies at Phase 3. Of the 19721 research sites hosting these experiments, many are situated in Los Angeles County." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.