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Loop Diuretic

Increased Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide) for Heart Failure

Phase 1

Waitlist Available

Led By Jeffrey Testani, MD

Research Sponsored by Yale University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 hours

Awards & highlights

Study Summary

This trial is testing whether or not diuretic drugs given to heart failure patients work better when they are tailored to the patient's individual needs.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Accuracy of prediction of mechanistic sub types of DR using universally available laboratory tests

Diuretics

Change in total 6-hour sodium output between observational and randomized intervention study days

+1 more

Secondary outcome measures

Prediction of mechanistic sub types of DR

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Loop Diuretic (Bumetanide or Furosemide) + IV ChlorothiazideExperimental Treatment1 Intervention

Loop diuretic (Bumetanide or Furosemide) dose remains the same as visit 1 dose but now with the addition of 500-1000 mg IV chlorothiazide

Group II: Increased Intravenous Loop Diuretic (Bumetanide or Furosemide)Experimental Treatment1 Intervention

2.5x Visit 1 dose

Group III: Observational ArmActive Control1 Intervention

Subjects taking an IV loop diuretic (Bumetanide or Furosemide) that have sodium output greater than 100 mmol. These subjects will continue to be followed and have data collected on them.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Increased Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide)

2015

Completed Phase 1

~460

IV Chlorothiazide

2015

Completed Phase 1

~460

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor

1,847 Previous Clinical Trials

2,736,070 Total Patients Enrolled

32 Trials studying Heart Failure

55,541 Patients Enrolled for Heart Failure

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,832 Previous Clinical Trials

47,305,888 Total Patients Enrolled

205 Trials studying Heart Failure

676,840 Patients Enrolled for Heart Failure

Jeffrey Testani, MDPrincipal InvestigatorYale University

6 Previous Clinical Trials

181 Total Patients Enrolled

3 Trials studying Heart Failure

131 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there openings available for participants in this trial?

"The information posted on clinicaltrials.gov reveals that this medical trial is no longer actively recruiting participants, its last update being made on July 21st 2022. However, there are currently an abundance of other trials in search for candidates which total 718 at present."

Answered by AI

How many study participants has this research enrolled?

"This trial is no longer seeking patients, having been initially posted on August 31st 2015 and most recently edited on July 21st 2022. Other studies concerning heart failure are ongoing with 700 trials accepting participants while 18 others looking at the effects of increased doses of bumetanide or furosemide have opened up recruitment."

Answered by AI

To what extent can administration of Bumetanide or Furosemide present a risk to patients?

"Our team at Power evaluated the safety of Increased Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide) to be a 1 due to the limited existing data regarding its efficacy and security."

Answered by AI

In what cases are increased doses of Bumetanide or Furosemide administered intravenously?

"Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide) is commonly used to reduce edema, but can also be taken for hypertension, chronic kidney disease and cirrhosis of the liver."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure

2015. "Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02546583.