All > Heart Failure With Preserved Ejection Fraction > Heart Failure

Lysine Chloride for Heart Failure

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Heart FailureLysine Chloride - Drug
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will study the effects of a salt-free diet on heart failure patients.

Eligible Conditions
  • Heart Failure

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

1
Lysine Chloride
1
Dexrazoxane
1
Bumetanide 1.25 mg

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: Daily for 7-days

Daily for 7-days
Change in Bicarbonate
Change in Blood Volume
Chlorides
Change in Cystatin C
Change in Serum Creatinine
Change in log NTpro-BNP

Trial Safety

Safety Progress

1 of 3

Similar Trials

1
Lysine Chloride
1
Dexrazoxane
1
Bumetanide 1.25 mg

Trial Design

2 Treatment Groups

Lysine Chloride
1 of 2
Placebo
1 of 2

Experimental Treatment

Non-Treatment Group

20 Total Participants · 2 Treatment Groups

Primary Treatment: Lysine Chloride · Has Placebo Group · Phase < 1

Lysine Chloride
Drug
Experimental Group · 1 Intervention: Lysine Chloride · Intervention Types: Drug
Placebo
Other
PlaceboComparator Group · 1 Intervention: Placebo · Intervention Types: Other
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lysine
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: daily for 7-days

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,589 Previous Clinical Trials
46,945,787 Total Patients Enrolled
193 Trials studying Heart Failure
673,244 Patients Enrolled for Heart Failure
Yale UniversityLead Sponsor
1,678 Previous Clinical Trials
21,087,793 Total Patients Enrolled
27 Trials studying Heart Failure
51,733 Patients Enrolled for Heart Failure

Eligibility Criteria

Age 18+ · All Participants · 8 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have heart failure with evidence of left ventricular hypertrophy and/or diastolic dysfunction.
You have chronic loop diuretic therapy with ≥ 40 mg of furosemide equivalents.
You have a serum chloride level of < 102 mmol/L.
References

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