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Growth Factor

VCMX + rhPDGF-BB for Dental Implant Healing

N/A

Waitlist Available

Led By I-Ching Wang, DDS,MS

Research Sponsored by I-Ching Wang

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adequate tooth space to support an immediate implant placement (i.e., adequate mesiodistal space of greater than or equal to 6 mm and interocclusal space to support a non-occluding provisionalization)

Has a single hopeless tooth in the maxillary esthetic zone (i.e., first premolar to first premolar, tooth #5-tooth #13)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement

Awards & highlights

Study Summary

This trial tests a combination of materials and growth factor to accelerate healing of implants placed in teeth #5-#12. Participants will attend 11 visits over 1.25 years.

Who is the study for?

This trial is for adults aged 18-95 who need an implant in the front upper jaw due to a failing tooth, have good oral hygiene, and a small bone defect after tooth removal. It's not for those with severe untreated gum disease, serious health conditions, pregnant women, patients on long-term meds affecting bones, history of head/neck radiation or heavy smokers.Check my eligibility

What is being tested?

The study tests if adding growth factor-BB to a collagen graft helps blood vessel formation and tissue volume around dental implants placed right after tooth extraction. Participants will receive this treatment and attend 11 visits over about 15 months.See study design

What are the potential side effects?

Potential side effects may include discomfort at the implant site, swelling, bruising or bleeding gums. There might also be risks related to the use of growth factors such as excessive tissue growth.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have enough space in my mouth for an immediate dental implant.

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I have one bad tooth in the front upper part of my mouth.

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I am between 18 and 95 years old.

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My tooth socket's outer wall bone loss is 3mm or less.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement

This trial's timeline: 3 weeks for screening, Varies for treatment, and multiple time points (i.e. 0, immediately after implant placement, 1 week, 2 weeks, 4 weeks, 6 weeks, 12 weeks, 16 weeks, 24 weeks, and 48 weeks after immediate implant placement for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in from Baseline in Soft and Hard Tissue Thickness as assessed by ultrasound.

Side effects data

From 2007 Phase 3 trial • 330 Patients • NCT00035815

62%

Depression

53%

Site reactions

33%

Respiratory failure

14%

Change in visual acuity

13%

Hypoglycemia

13%

Headache

11%

Thrombotic events

Hepatotoxicity

Abnormal blood chemistries (other than liver)

100%

80%

60%

40%

20%

Study treatment Arm

IGF-1

Placebo

Trial Design

1Treatment groups

Experimental Treatment

Group I: Xenogeneic Volume-Stable Collagen (VCMX) graft with growth factor-BBExperimental Treatment1 Intervention

Subjects in this arm will have a xenogeneic volume-stable collagen matrix in combination with recombinant human platelet-derived growth factor-BB at the time of immediate implant placement.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

I-Ching WangLead Sponsor

I-Ching Wang, DDS,MSPrincipal InvestigatorUniversity of Iowa

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this medical trial available to geriatric patients?

"As stipulated by the requirements for participation, this clinical trial has a minimum age of 18 and maximum age of 95."

Answered by AI

Could I be a candidate to partake in this research?

"To be eligible to partake in this clinical trial, applicants must have had dental extractions and fall between 18-95 years old. Currently there are 12 slots available for participants."

Answered by AI

Are there any vacancies remaining for those wishing to participate in this clinical trial?

"Clinicaltrials.gov has updated information indicating that this trial, which was initially posted on January 1st 2024, is not currently recruiting patients. However, 11 other trials are actively enrolling participants at the moment of writing."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB

I-Ching Wang 2025. "Immediate Implant Placement Using Volume-Stable Collagen Matrix Combined With rhPDGF-BB". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06038695.