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Antiseptics for Dental Implant Success

Phase < 1
Recruiting
Research Sponsored by Madigan Army Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Aged 18-55 years old
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up four months post dental implant insertion.
Awards & highlights

Study Summary

This trialwill explore if using disinfectants in dental implants can reduce infection and improve success rates for soldiers at risk of poor dentition.

Who is the study for?
This trial is for active duty military personnel aged 18-55 with over 6 months remaining at their local station. It's not for tobacco users, those with metabolic disorders affecting healing, active gum disease, or anyone on medication that impacts tissue or bone recovery.Check my eligibility
What is being tested?
The study tests if disinfectant gels (hydrogen peroxide or chlorhexidine) can reduce bacterial load and change the microbiome in dental implants to prevent failure. Participants will receive one of these antiseptics directly into the implant cavity.See study design
What are the potential side effects?
Potential side effects may include irritation at the application site within the mouth, altered taste sensation, tooth staining, and possibly a mild burning feeling when using either hydrogen peroxide or chlorhexidine gel.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 55 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~four months post dental implant insertion.
This trial's timeline: 3 weeks for screening, Varies for treatment, and four months post dental implant insertion. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Implant Failure
Secondary outcome measures
Bacterial Load
Microbiome Composition
Peri-Implantitis

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Hydrogen PeroxideExperimental Treatment1 Intervention
Hydrogen Peroxide treatment.
Group II: ChlorhexidineExperimental Treatment1 Intervention
Chlorhexidine treatment.
Group III: ControlActive Control1 Intervention
This arm will receive standard of care during dental implant insertion.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Chlorhexidine
2013
Completed Phase 4
~9050
Hydrogen Peroxide
2017
Completed Phase 3
~1640

Find a Location

Who is running the clinical trial?

United States Department of DefenseFED
861 Previous Clinical Trials
227,044 Total Patients Enrolled
Madigan Army Medical CenterLead Sponsor
48 Previous Clinical Trials
18,054 Total Patients Enrolled

Media Library

Hydrogen Peroxide Clinical Trial Eligibility Overview. Trial Name: NCT05024760 — Phase < 1
Peri-Implantitis Research Study Groups: Hydrogen Peroxide, Control, Chlorhexidine
Peri-Implantitis Clinical Trial 2023: Hydrogen Peroxide Highlights & Side Effects. Trial Name: NCT05024760 — Phase < 1
Hydrogen Peroxide 2023 Treatment Timeline for Medical Study. Trial Name: NCT05024760 — Phase < 1
Peri-Implantitis Patient Testimony for trial: Trial Name: NCT05024760 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the eligibility criteria for this research extend towards individuals of an advanced age?

"Only individuals who are above the age of majority and under 55 years old can participate in this medical trial."

Answered by AI

What are the prerequisites for enrolling in this clinical trial?

"In order to meet the criteria for this clinical experiment, potential participants should possess peri-implantitis and be between 18 and 55 years of age. This research effort is currently in need of 150 individuals."

Answered by AI

In what diseases and conditions is Hydrogen Peroxide utilized?

"Hydrogen Peroxide is widely employed to prevent sepsis, but may also be beneficial in addressing issues such as disinfection, sore throats and pressure ulcers."

Answered by AI

How many research subjects are involved in this investigation?

"Affirmative. Clinicaltrials.gov shows that this investigation, which was initially advertised on July 28th 2022, is currently recruiting subjects. This project requires 150 volunteers from only one medical site for participation."

Answered by AI

Are individuals being accepted into this research effort presently?

"Affirmative. According to the clinical trials website, this study is actively recruiting for 150 participants across a single site. It was initially posted on July 28th 2022 and its details have been updated most recently on January 19th 2023."

Answered by AI

Who else is applying?

What state do they live in?
Utah
Missouri
Oregon
What site did they apply to?
Madigan Army Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
3+
0

Why did patients apply to this trial?

I am hoping to try dental implants. I have full upper and lower partial denture. ive just had the rest of my lower teeth pulled and i am despert to get 2 implants to hold mylowerdenture in.
PatientReceived 2+ prior treatments
One side of my upper snap in denture will not hold the implant. I had these done in Mexico. I just need to be able to eat properly. Any help would be greatly appreciated.
PatientReceived no prior treatments
I currently have upper dentures and I have rotten teeth that are going to get extracted soon so that I can get dental implants. I really need the. My dentures don't feel right or look right. When i look in the mirror I don't see myself anymore. The dentures have broken several times and I've had to use superglue.
PatientReceived 1 prior treatment
Recent research and studies
clinicaltrials.govStudy
Antiseptic Effects on the Dental Implant Internal Surface Microbiome
2022. "Antiseptic Effects on the Dental Implant Internal Surface Microbiome". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05024760.
All > Dental Implant > Microbiome
~56 spots leftby Apr 2025
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