Hydrogen Peroxide for Peri-Implantitis

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Peri-Implantitis+3 MoreChlorhexidine - Drug
Eligibility
18 - 55
All Sexes
What conditions do you have?
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Study Summary

Soldiers operate in environments that are more likely to lead to oral trauma, risking poor dentition which can directly impact military readiness. Dental restoration can often be accomplished via dental implant insertion. Microbiome-associated complications that result in bone loss, including the micro-leakage of bacterial species proliferating in the dental implant internal cavity, frequently lead to implant failure. Reduction in implant bacterial load may result in a shift of the composition of the microbiome in favor of less pathogenic species, potentially improving dental implant success rates, reducing surgical revisions, and associated cost savings. This study aims to determine how disinfectant gel (hydrogen peroxide or chlorhexidine) insertion into dental implant internal cavities affects implant failure rates, bacterial load and microbiome composition.

Eligible Conditions
  • Peri-Implantitis
  • Peri-implant Mucositis
  • Implant Infection
  • Dental Implant Failure

Treatment Effectiveness

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: Four months post dental implant insertion.

Four months post dental implant insertion.
Bacterial Load
Implant Failure
Microbiome Composition
Peri-Implantitis

Trial Safety

Trial Design

3 Treatment Groups

Control
1 of 3
Hydrogen Peroxide
1 of 3
Chlorhexidine
1 of 3

Active Control

Experimental Treatment

150 Total Participants · 3 Treatment Groups

Primary Treatment: Hydrogen Peroxide · No Placebo Group · Phase < 1

Hydrogen Peroxide
Drug
Experimental Group · 1 Intervention: Hydrogen Peroxide · Intervention Types: Drug
Chlorhexidine
Drug
Experimental Group · 1 Intervention: Chlorhexidine · Intervention Types: Drug
ControlNoIntervention Group · 1 Intervention: Control · Intervention Types:
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Chlorhexidine
FDA approved
Hydrogen peroxide
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: four months post dental implant insertion.

Who is running the clinical trial?

United States Department of DefenseFED
777 Previous Clinical Trials
202,347 Total Patients Enrolled
Madigan Army Medical CenterLead Sponsor
48 Previous Clinical Trials
18,415 Total Patients Enrolled

Eligibility Criteria

Age 18 - 55 · All Participants · 3 Total Inclusion Criteria

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References