Colonoscopy vs Fecal Occult Blood Test for Colorectal Cancer Screening
(00-046 Trial)
Trial Summary
What is the purpose of this trial?
RATIONALE: Screening tests, such as colonoscopy and fecal occult blood test, may help doctors find tumor cells early and plan better treatment for colorectal cancer.PURPOSE: This randomized phase III trial is studying colonoscopy to see how well it works compared to fecal occult blood test in screening healthy participants for colorectal cancer.
Research Team
Ann Zauber, PhD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Eligibility Criteria
Healthy individuals aged 50-69 (40-69 at one site), at average risk for colorectal cancer, with no serious health issues or history of certain bowel diseases. Participants should not have had a colonoscopy before and must avoid red meat and certain medications around the time of testing.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Screening
Participants undergo baseline screening colonoscopy or fecal occult blood test (FOBT)
Annual Follow-up
Participants with negative baseline FOBT undergo FOBT annually for up to 4 years
Follow-up
All participants are followed annually for up to 4 years to monitor outcomes
Treatment Details
Interventions
- annual screening
- fecal occult blood test
- screening colonoscopy
- standard follow-up care
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator