Combination Chemotherapy + Cyclosporine and Focal Therapy for Retinoblastoma
What You Need to Know Before You Apply
What is the purpose of this trial?
RATIONALE: Drugs used in chemotherapy, such as carboplatin, etoposide, and vincristine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Sometimes when chemotherapy is given, it does not stop the growth of tumor cells. The tumor is said to be resistant to chemotherapy. Giving cyclosporine together with chemotherapy may reduce drug resistance and allow the tumor cells to be killed. Cryotherapy kills tumor cells by freezing them. Laser therapy uses light to kill tumor cells. Giving combination chemotherapy together with cyclosporine followed by cryotherapy and/or laser therapy may be an effective treatment for retinoblastoma.PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with cyclosporine followed by cryotherapy and/or laser therapy works in treating patients with newly diagnosed retinoblastoma in both eyes.
Who Is on the Research Team?
Helen SL Chan, MD, BS
Principal Investigator
The Hospital for Sick Children
Elise Heon, MD
Principal Investigator
The Hospital for Sick Children
Brenda L Gallie, MD
Principal Investigator
The Hospital for Sick Children
Are You a Good Fit for This Trial?
This trial is for patients with bilateral retinoblastoma, a type of eye cancer, specifically those with IIRC Group B, C, or D disease in at least one eye. Suitable participants are over 30 days old and have normal liver and kidney function tests. Those with unilateral retinoblastoma, metastatic disease, or very young infants under 30 days old cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive high-dose carboplatin, etoposide, vincristine, and cyclosporine chemotherapy followed by focal therapy with cryotherapy and/or laser therapy
Focal Therapy
Participants undergo additional cryotherapy and/or laser therapy for tumor consolidation
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Carboplatin
- Cryosurgery
- Cyclosporine
- Etoposide
- Laser Therapy
- Vincristine sulfate
Carboplatin is already approved in United States, European Union, Canada for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Hospital for Sick Children
Lead Sponsor
Terry Fox Foundation
Collaborator