Multi-Channel Intervention for Colorectal Cancer Screening

(YVONNE Trial)

Overseen By Adam Alexander, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Oklahoma

Disqualifiers: Up to date CRC screening

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores new ways to encourage colorectal cancer screening among American Indian communities in Oklahoma. It tests two approaches: watching a video testimonial from a Tribal community health educator (Narrative Testimonial Video) and interacting with a virtual Tribal community health educator (v-TCHE). The researchers aim to determine which method better promotes screening and helps overcome barriers to testing. American Indians living in the IHS Clinton Service Unit area who haven't been screened for colorectal cancer recently might be a good fit for this trial. Participants can order a free FIT kit (a home test for colon cancer) after completing the trial. As an unphased trial, this study offers a unique opportunity to contribute to innovative strategies for improving health outcomes in the community.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that using video testimonials as a health tool is generally safe. Videos featuring personal stories about colorectal cancer screening, such as the Narrative Testimonial Video, aim to inform and motivate people without physical risks. They present information in a relatable way, encouraging viewers to consider early detection.

The v-TCHE (virtual Tribal Community Health Educator) Interaction builds trust and engages users. Early findings suggest participants feel comfortable with it. This virtual interaction addresses personal concerns and aids in decisions about colorectal cancer screening. Since it involves no physical procedures, it is considered safe for participants.

Both methods are non-invasive and focus on sharing information. No reports of negative effects have emerged from these methods, making them safe options for those considering joining the study. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Multi-Channel Intervention for Colorectal Cancer Screening because it offers culturally tailored approaches that could enhance screening uptake. The Narrative Testimonial Video features a Tribal community health educator sharing personal stories, making it relatable and potentially more persuasive for American Indian audiences. Meanwhile, the v-TCHE Interaction allows users to engage with a virtual Tribal Community Health Educator using Google’s advanced speech recognition, addressing individual concerns and empowering informed decision-making. Unlike standard mass media campaigns or impersonal reminders, these personalized, culturally relevant interactions could significantly increase screening rates and early detection, which is crucial for better outcomes in colorectal cancer.

What evidence suggests that this trial's interventions could be effective for colorectal cancer screening?

Research has shown that storytelling videos, such as the Narrative Testimonial Video, can make information about colorectal cancer screening more relatable and help overcome common obstacles. People who watch these short videos often feel more motivated to get screened. Participants in this trial may receive this intervention.

The v-TCHE Interaction, another intervention in this trial, is designed to build trust and make the screening process feel more approachable by allowing participants to share their thoughts and interact. Although specific data on v-TCHE's effectiveness is limited, it aims to empower people to make informed decisions and address their concerns in a personalized way.

Both methods in this trial aim to increase colorectal cancer screening rates by making the information personal and engaging. ^{6 7 8 9 10}

Who Is on the Research Team?

Jordan Neil, PhD

Principal Investigator

University of Oklahoma

Are You a Good Fit for This Trial?

This trial is for American Indians in Oklahoma focusing on increasing colorectal cancer screening rates. Participants should be part of the community served by the IHS Clinton Service Unit, which includes members of the Cheyenne and Arapaho Tribes. Specific eligibility criteria are not detailed here.

Inclusion Criteria

I am between 45 and 75 years old.

Live within IHS Clinton Service Unit catchment area

Fluent in English and read at or above 6th grade level

Exclusion Criteria

Self report up to date with CRC screening FIT within 1 year

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention Development

Co-development of a multi-channel communication intervention with AI in Oklahoma, including focus groups and creation of v-TCHE and Narrative Testimonial Video

8-12 weeks

Intervention

Participants engage with the intervention via Social Media or Clinic channels, randomized to either Narrative Testimonial Video or v-TCHE interaction

4 weeks

Online engagement

Follow-up

Participants are monitored for engagement and efficacy, including ordering and returning FIT kits and completing post-intervention surveys

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Narrative Testimonial Video
• v-TCHE Interaction

Trial Overview The study tests a multi-channel communication intervention to promote colorectal cancer screening. It compares two methods: watching a narrative testimonial video versus interacting with a virtual Tribal Community Health Educator (v-TCHE). The effectiveness will be measured through reach and potential efficacy in a randomized controlled trial.

How Is the Trial Designed?

Group I: Narrative Testimonial Video of a Tribal Community Health Educator Active Control 1 Intervention

The narrative testimonial will provide a first-person recording of a real Tribal community health educator. In addition to the kernel information, the narrative video will employ culturally concordant storytelling about their personal experiences helping AI patients get screened and positive outcomes associated with early detection.

Group II: v-TCHE Interaction Active Control 1 Intervention

Participants can interact via a set of authored responses or speak freely to the vTCHE. The v-TCHE uses Google Speech-to-Text to convert participant speech into text and Google's DialogFlow logs participants' selections, utterances, and interactions with the vTCHE. The interaction will elicit individual preferences, address concerns about CRC, and empower decision-making while still promoting CRC screening.

Who Is Running the Clinical Trial?

University of Oklahoma

Lead Sponsor

Trials

484

Recruited

95,900+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6543268/

How narratives influence colorectal cancer screening ... We identified four mechanisms: (a) process narratives that address perceived barriers towards screening lead to improved affective forecasting, (b) experience ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT02100254

Narrative or Fact-Based Videos in Increasing Colorectal ... It is not yet known whether narrative videos may be more effective than fact-based videos in increasing colorectal cancer screenings. Detailed Description.

3. onlinelibrary.wiley.com onlinelibrary.wiley.com/doi/full/10.1111/jrh.12828

Comparative effectiveness of two interventions to increase ... To assess the comparative effectiveness of a tailored, interactive digital video disc (DVD) intervention versus DVD plus patient navigation (PN) intervention ...

4. sciencedirect.com sciencedirect.com/science/article/pii/S0738399125005944

Consumer perspectives on videos for promoting ... In an online survey, 487 people eligible for Australia's National Bowel Cancer Screening Program were randomly assigned to view 2–3 of a ...

5. psycnet.apa.org psycnet.apa.org/record/2026-30624-001

Brief video interventions increase screening intentions in ... Brief video interventions increase screening intentions in people who avoid colorectal cancer information. Citation.

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC6882758/

YouTube Videos as a Source of Information on Colorectal ... It is important to assess whether the information delivered by videos on colorectal cancer is accurate or misleading as patients, relatives, and other members ...

7. youtube.com youtube.com/watch?v=OjyCA-MgTkc

John's Shield™ Story: Getting Screened For Colon Cancer The Shield blood test was a very noninvasive way to get very accurate results patients will recognize right away that this is an easy fast test.

8. uclahealth.org uclahealth.org/medical-services/gastro/colon-cancer-screening/awareness-campaign/our-stories

Colon Cancer Survivor Stories - Colorectal Cancer Screening Hear from colon cancer survivors as they describe their symptoms, how they knew they had colon cancer, and more in these patient stories.

9. youtube.com youtube.com/watch?v=eelvXptMj5Q

Rick's Story | Colon Cancer Screening Fear keeps many from getting screened for colon cancer. But Rick's story shows how support, community and open communication around a ...

10. cancer.org cancer.org/cancer/types/colon-rectal-cancer/colon-cancer-videos.html

Colorectal Cancer Videos | Risk, Screening, & Treatment Watch videos about colon cancer risk factors, screening tests, and treatments. There are also personal stories from colon cancer survivors.