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Non-invasive Brain Stimulation

Multi-Modality Aphasia Therapy (M-MAT) for Aphasia (REMAP Trial)

N/A
Waitlist Available
Led By Sean P Dukelow, MD PhD FRCPC
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and 3-month follow-up
Awards & highlights

REMAP Trial Summary

This trial is testing whether a specific type of brain stimulation called repetitive transcranial magnetic stimulation (rTMS), given soon after a stroke, can help people with aphasia.

Eligible Conditions
  • Aphasia
  • Stroke

REMAP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and 3-month follow-up
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and 3-month follow-up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change from baseline on the Western Aphasia Battery (Revised) Aphasia Quotient at 3 months
Change from baseline on the Western Aphasia Battery (Revised) Aphasia Quotient within one week of intervention completion
Secondary outcome measures
Apraxia Battery for Adults (ABA)
Cognitive Linguistic Quick Test - aphasia administration
Communication Effectiveness Index
+10 more

REMAP Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Multi-modality aphasia therapy plus 1Hz rTMSExperimental Treatment2 Interventions
Participants receive 10 days of 3.5hrs of multi-modality aphasia therapy (M-MAT) preceded by 20 minutes of 1Hz rTMS delivered at 100% of resting motor threshold over the right pars triangularis.
Group II: Multi-modality aphasia therapy plus sham rTMSPlacebo Group2 Interventions
Participants receive 10 days of 3.5hrs of multi-modality aphasia therapy (M-MAT) preceded by 20 minutes of sham rTMS is achieved using a sham TMS coil which attenuates the magnetic output of the stimulator by 80%.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Multi-Modality Aphasia Therapy (M-MAT)
2018
N/A
~70
1Hz inhibitory rTMS
2018
N/A
~70

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
791 Previous Clinical Trials
868,688 Total Patients Enrolled
1 Trials studying Aphasia
20 Patients Enrolled for Aphasia
Sean P Dukelow, MD PhD FRCPCPrincipal InvestigatorUniversity of Calgary

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants will be included in this research project?

"Affirmative. Clinicaltrials.gov indicates that this clinical trial is actively seeking participants, with the initial post dated April 15th 2021 and last update on October 14th 2022. 100 volunteers need to be recruited from a single site."

Answered by AI

Is this clinical trial open to new participants at present?

"This clinical trial is currently enlisting candidates, according to information provided by clinicaltrials.gov. The medical research project was initially published on April 15th 2021 and edited most recently on October 14th 2022."

Answered by AI

What are the primary goals that this clinical trial is hoping to achieve?

"The primary aim of this clinical trial, to be measured at Baseline and 3 months post-treatment, is to evaluate the transformation in patient's Western Aphasia Battery (Revised) Aphasia Quotient score. Secondary objectives include assessing narrative/descriptive discourse with a Sequential Picture Description task, testing functional communication ability via a Scenario Test (UK), and gauging characteristics of verbal apraxia using an Apraxia Battery for Adults."

Answered by AI

Who else is applying?

What state do they live in?
California
How old are they?
65+
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia
Dr. Sean Dukelow 2021. "Repetitive Transcranial Magnetic Stimulation and Multi-modality Aphasia Therapy for Post-stroke Non-fluent Aphasia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04102228.
~11 spots leftby Apr 2025
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