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rTMS for Opioid Use Disorder (TOTS Trial)
TOTS Trial Summary
This trial is studying whether a certain brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with opioid use disorder who are starting methadone treatment.
TOTS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTOTS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.TOTS Trial Design
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Who is running the clinical trial?
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- I use alcohol and/or marijuana less than 4 times a week, within the specified limits.I am a male or a female not currently pregnant or breastfeeding.I am between 21 and 70 years old.My cognitive abilities are intact.I do not have any health issues that prevent me from using rTMS.I have not treated or controlled my depression, anxiety, OCD, or PTSD in the past year.I have ongoing pain in my head or neck.I am not taking any medications that are not allowed in the study.
- Group 1: Active 10 Hz dlPFC rTMS
- Group 2: Sham dlPFC rTMS
- Group 3: Active 1 Hz mPFC rTMS
- Group 4: Sham mPFC
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Could I have the opportunity to join this medical trial?
"This medical trial requires enrollees to be between 21 and 60 years old, with a diagnosis of opioid use disorder (OUD). The maximum capacity for this study is 32 individuals."
How many participants are currently receiving treatment under this clinical trial?
"Yes, according to clinicaltrials.gov the trial is actively seeking participants. This study was initially posted on April 1st 2022 and subsequently revised on April 26th 2022 with a goal of recruiting 32 patients from one location."
What aims are researchers seeking to accomplish with this trial?
"The main metric of this experiment, which involves a sham-to-active condition transition (scheduled between days 6 and 12, alongside 18 to 24), is the Wisconsin Card Sorting Task perseverance score. Secondary objectives include measuring State Anxiety subscale scores from the State-Trait Anxiety Inventory with lower numbers implying better outcomes, Positive and Negative Affect Scale total score with lesser amounts of negative affect representing improved results, as well as Monetary delay discounting where higher area under curve figures (preferring delayed money) point towards superior performance."
Is there still time to enroll in this medical experiment?
"As per the information presented on clinicaltrials.gov, this trial is actively searching for participants to join. It was posted online April 1st 2022 and modified most recently on April 26th of the same year."
Is this medical research open to seniors above the age of seventy?
"To fulfil the entrance requirements for this study, applicants must be between 21 and 60 years old. Additionally, there are 89 clinical trials specifically designed to accommodate people under 18 while 400 other studies exist aimed at those over 65."
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