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Behavioral Intervention

Stress and Relaxation Effects on Alzheimer's Disease Markers

N/A

Recruiting

Research Sponsored by University of Southern California

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 9.5 hours

Awards & highlights

Study Summary

This trial will study whether exposure to stress increases levels of a protein associated with Alzheimer's disease, and whether relaxation can decrease those levels.

Who is the study for?

This trial is for healthy adults who haven't fainted during blood draws, aren't lactating or pregnant in the past year, don't have chronic illnesses, and aren't on medications that affect stress responses. Participants must be non-smokers, fluent in English, not afraid of blood draws, weigh at least 110 pounds and can’t have cardiovascular issues or mood disorders.Check my eligibility

What is being tested?

The study investigates if short-term stress increases amyloid-beta levels in the blood—a marker linked to Alzheimer's disease. It looks at how the body reacts to stress by measuring these levels over five hours after a stressful event.See study design

What are the potential side effects?

Since this trial involves sympathetic nervous system activation through stress exposure rather than medication intake, side effects may include temporary discomfort from the cold pressor test and anxiety due to being filmed during the task.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 9.5 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~9.5 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 9.5 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Plasma amyloid-beta-40

Plasma amyloid-beta-42

Secondary outcome measures

Urinary amyloid-beta-42

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Stress (sympathetic nervous system activation)Experimental Treatment1 Intervention

Stress will be induced using the socially evaluated cold pressor test. Participants will complete three rounds of the socially evaluated cold pressor test. The socially evaluated cold pressor test involves submerging one hand in ice-cold water for 3 minutes while participants' reactions are filmed on camera.

Group II: No-stressPlacebo Group1 Intervention

Participants will hold a hand in room temperature water for 3 minutes.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Keck School of Medicine of USCOTHER

5 Previous Clinical Trials

672 Total Patients Enrolled

Washington University School of MedicineOTHER

1,936 Previous Clinical Trials

2,299,652 Total Patients Enrolled

University of Southern CaliforniaLead Sponsor

906 Previous Clinical Trials

1,596,250 Total Patients Enrolled

Media Library

No-stress (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05521919 — N/A

Stress Reaction Clinical Trial 2023: No-stress Highlights & Side Effects. Trial Name: NCT05521919 — N/A

Stress Reaction Research Study Groups: No-stress, Stress (sympathetic nervous system activation)

No-stress (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05521919 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this trial include elderly individuals as participants?

"The age criteria for this experiment requires that patients be above 18 and below 70 years of age."

Answered by AI

Am I eligible to join this research program?

"Currently, this trial is searching for 38 individuals with a cardiac rhythm between 18-70 years of age. The ideal candidate should weigh at least 110 pounds and not take any medications that could interfere with their stress response (e.g., beta blockers). In addition, they must have no contraindications to the cold pressor test exposure like high blood pressure or diabetes; furthermore, applicants cannot be suffering from fainting spells or seizures nor can they harbor phobias towards blood draws or current mood disorders such as major depression."

Answered by AI

Is this research currently recruiting participants?

"This clinical trial, which was initially publicized on December 1st 2022 and last updated on November 8th 2022, is currently not recruiting participants. Despite this fact, there are 593 other studies that are presently enrolling individuals into their research efforts."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Acute Plasma Abeta Responses to Stress

Mara Mather 2024. "Acute Plasma Abeta Responses to Stress". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05521919.