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Water Ingestion for Heart Transplant Patients

N/A
Waitlist Available
Led By Satish R Raj, MD, MSCI
Research Sponsored by Satish R. Raj
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients who have undergone cardiac transplantation and are scheduled for clinical right heart catheterization
Patients aged over 18 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 40 min (before to 30 min after water ingestion
Awards & highlights

Study Summary

This trial will test whether water ingestion increases systemic vascular resistance.

Who is the study for?
This trial is for heart transplant patients over 18 years old who are scheduled for a clinical right heart catheterization. It's not suitable for those with significant tricuspid regurgitation, difficulty swallowing large amounts of water, or severe kidney disease where drinking water could be harmful.Check my eligibility
What is being tested?
The study is examining the effects of drinking 16 fl oz of water on blood vessel resistance in heart transplant recipients. The goal is to see if consuming this amount of water will increase the resistance in systemic blood vessels.See study design
What are the potential side effects?
Since the intervention involves only ingesting water, no direct side effects are expected from the treatment itself; however, participants with certain health conditions were excluded to prevent potential harm.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have had a heart transplant and am scheduled for a heart catheterization.
Select...
I am over 18 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~40 min (before to 30 min after water ingestion
This trial's timeline: 3 weeks for screening, Varies for treatment, and 40 min (before to 30 min after water ingestion for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in total vascular resistance
Secondary outcome measures
blood pressure
heart rate
Norepinephrine

Side effects data

From 2007 Phase 3 trial • 67 Patients • NCT01021007
24%
discomfort in mouth or body
9%
slight swelling or inflammation of the gums
3%
Tooth staining
100%
80%
60%
40%
20%
0%
Study treatment Arm
Negative Control Rinse
Iocide Mouthrinse

Trial Design

1Treatment groups
Experimental Treatment
Group I: 1Experimental Treatment1 Intervention
water ingestion
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
water
2006
Completed Phase 4
~8920

Find a Location

Who is running the clinical trial?

National Center for Research Resources (NCRR)NIH
537 Previous Clinical Trials
316,976 Total Patients Enrolled
Satish R. RajLead Sponsor
6 Previous Clinical Trials
490 Total Patients Enrolled
Satish R Raj, MD, MSCIPrincipal InvestigatorVanderbilt University Medical Center
4 Previous Clinical Trials
247 Total Patients Enrolled

Media Library

water Clinical Trial Eligibility Overview. Trial Name: NCT00581321 — N/A
water 2023 Treatment Timeline for Medical Study. Trial Name: NCT00581321 — N/A
Heart Transplant Research Study Groups: 1
Heart Transplant Clinical Trial 2023: water Highlights & Side Effects. Trial Name: NCT00581321 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies still available for participants in this research?

"According to clinicaltrials.gov, the recruitment of patients for this study has been completed with the last edit on September 12th 2022. However, there are numerous other research studies currently recruiting participants - 105 in total at present."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Oral Water Ingestion in Heart Transplant Patients
Satish R. Raj 2006. "Oral Water Ingestion in Heart Transplant Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00581321.
All > Blood Pressure
~3 spots leftby Dec 2025
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