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Exercise-Induced Kidney Blood Flow Response in African American Adults

N/A
Waitlist Available
Led By Rachel C Drew, PhD
Research Sponsored by University of Massachusetts, Boston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up pre-acute exercise and during steady-state exercise
Awards & highlights

Study Summary

This trial will study the renal vasoconstrictor response to sympathetic stressors in healthy African American adults prior to development of cardiovascular and renal disease to test the hypotheses that the renal vasoconstrictor response to acute dynamic exercise, as well as a cold pressor and mental stress tests, is exaggerated in healthy young African American adults compared to white adults.

Who is the study for?
This trial is for African American and White adults born in the U.S., fluent in English, who are active but not training competitively. Participants must have parents of the same racial identity. It excludes pregnant or lactating women, those with hypertension, diabetes, obesity, smokers, or anyone with cardiovascular/renal disease.Check my eligibility
What is being tested?
The study investigates how acute exercise and stress tests (cold pressor test and mental stress test) affect kidney blood flow in healthy African American adults compared to Whites. The goal is to understand if there's an exaggerated response that could contribute to higher rates of cardiovascular and renal diseases.See study design
What are the potential side effects?
Since this trial involves non-drug interventions like exercise and stress tests rather than medications, side effects may include temporary discomfort from cold exposure during the cold pressor test or increased heart rate and blood pressure due to exercise or mental stress.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~pre-acute exercise and during steady-state exercise
This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-acute exercise and during steady-state exercise for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in renal vascular resistance during acute exercise
Change in renal vascular resistance during cold pressor test
Change in renal vascular resistance during mental stress test
Secondary outcome measures
Change in cardiac output during acute exercise
Change in cardiac output during cold pressor test
Change in cardiac output during mental stress test
+21 more
Other outcome measures
Rating of cold perception during cold pressor test
Rating of hand pain during cold pressor test
Rating of perceived exertion during acute exercise
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: White AdultsExperimental Treatment3 Interventions
White adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.
Group II: African American AdultsExperimental Treatment3 Interventions
African American adults will undergo the interventions of acute exercise, a cold pressor test, and a mental stress test while beat-to-beat renal blood flow velocity, mean arterial blood pressure, and heart rate are recorded.

Find a Location

Who is running the clinical trial?

University of Massachusetts, BostonLead Sponsor
34 Previous Clinical Trials
15,570 Total Patients Enrolled
Rachel C Drew, PhDPrincipal InvestigatorUniversity of Massachusetts, Boston

Media Library

Acute exercise Clinical Trial Eligibility Overview. Trial Name: NCT03981640 — N/A
Acute Exercise Research Study Groups: African American Adults, White Adults
Acute Exercise Clinical Trial 2023: Acute exercise Highlights & Side Effects. Trial Name: NCT03981640 — N/A
Acute exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT03981640 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What goals is this research attempting to achieve?

"The primary outcome of this trial—which will be assessed through pre- and post-mental stress tests over a 5 minute time frame—will measure the alteration in renal vascular resistance during acute exercise. Secondary outcomes include the absolute change from pre-cold pressor test to 30 second intervals during cold pressor testing, mean arterial blood pressure changes throughout 1 minute increments of mental stress testing, as well as heart rate discrepancies before and after steady state exercising."

Answered by AI

Could I be accepted as a participant in this clinical experiment?

"This medical trial is recruiting 32 adolescents aged between 18 to 35 with acute exercise. Candidates must be proficient in English, of African American or White descent, born in the USA, have two parents of the same race as themselves and should usually partake in physical activity for at least 20 minutes daily three times a week without training for competitive purposes."

Answered by AI

Are there any opportunities for volunteers to participate in this experiment?

"Clinicaltrials.gov records indicate that this medical study is currently not recruiting patients, having last been updated on June 16th 2022 since its original posting on July 1st 2023. Fortunately, there are still five other trials seeking participants at the moment."

Answered by AI

Is enrollment open to geriatric individuals for this investigation?

"As stated in the eligibility criteria for this medical trial, potential participants must be within the age range of 18 to 35 years old."

Answered by AI
~21 spots leftby Apr 2025