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auto-titrating for Obstructive Sleep Apnea

N/A
Waitlist Available
Led By R John Kimoff, MD, FRCP(C)
Research Sponsored by McGill University Health Centre/Research Institute of the McGill University Health Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks and 12 weeks after initial intervention
Awards & highlights

Study Summary

The primary objective is to evaluate the relative effectiveness of fixed CPAP in comparison to APAP in reducing arterial blood pressure in patients with resistant hypertension and obstructive sleep apnea (OSA). The secondary objectives are: a) to evaluate the relative effectiveness of fixed CPAP versus APAP in improving arterial stiffness, sleep-disordered breathing, sleep quality, inflammatory markers and glucose regulation; b) to identify specific characteristic of persons who respond to the two CPAP modalities in order to identify which device is better for each subject.

Eligible Conditions
  • High Blood Pressure (Hypertension)
  • Obstructive Sleep Apnea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks and 12 weeks after initial intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks and 12 weeks after initial intervention for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
24 hour blood pressure.
Secondary outcome measures
Blood tests to assess levels of aldosterone, hsCRP, fasting glucose, HbA1c, and plasma insulin.
Non-invasive measures of arterial stiffness using applanation tonometry.
Standard measures of OSA severity, including AHI and measures of nocturnal oxygenation and sleep quality using polysomnography.

Trial Design

2Treatment groups
Active Control
Group I: auto-titratingActive Control1 Intervention
Patients being treated for 6 weeks with auto-titrating continuous airway pressure.
Group II: FixedActive Control1 Intervention
Patients receiving 6 weeks of treatment with fixed continuous positive airway pressure.

Find a Location

Who is running the clinical trial?

OSR Medical Inc.Industry Sponsor
1 Previous Clinical Trials
264 Total Patients Enrolled
McGill University Health Centre/Research Institute of the McGill University Health CentreLead Sponsor
447 Previous Clinical Trials
159,718 Total Patients Enrolled
R John Kimoff, MD, FRCP(C)Principal InvestigatorMcGill University Health Centre/Research Institute of the McGill University Health Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness
Dr. Stella Daskalopoulou 2009. "Effect of Continuous Positive Airway Pressure (CPAP) Versus Auto-titrating Continuous Positive Airway Pressure (APAP) on Resistant Hypertension (HTN) and Arterial Stiffness". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01044355.
All > High Blood Pressure
~2 spots leftby May 2025
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