Granulomatosis With Polyangiitis Clinical Trials
Here are the 0 most popular medical studies for granulomatosis with polyangiitis
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Wegener's Granulomatosis Clinical Trials
View 6 Wegener's Granulomatosis medical studies.
Opioid Antagonist
Naltrexone for Vasculitis
This trial is testing a drug called naltrexone to see if it can improve quality of life for people with vasculitis. Naltrexone is a drug that is approved for treating alcoholism, but is being used “off-label” to treat pain. There have been a few studies done on the drug in three conditions (fibromyalgia, Crohn's disease, and multiple sclerosis) that suggest the drug is effective and safe. This trial is a pilot study, which means it is small, and has a placebo group to compare the results to.
Immunomodulator
Abatacept +1 More for Wegener's Granulomatosis
This trial is looking at whether abatacept can help people with GPA achieve remission without the use of glucocorticoids. People will be given either abatacept or a placebo once a week for at least 12 months. If they don't achieve remission or have a disease flare-up, they may be given abatacept in an open-label trial period.
Granulomatosis With Polyangiitis Clinical Trials With No Placebo
View 10 granulomatosis with polyangiitis medical studies that do not have a placebo group.
Monoclonal Antibodies
Reslizumab for Asthma
Reslizumab is a type of medicine called a monoclonal antibody that is made in the research clinic; it works by blocking a specific protein in the body called interleukin-5. The study medicine, reslizumab, is not yet approved for doctors to treat patients with EGPA. It is considered an experimental drug in this study.
Frequently Asked Questions
Introduction to granulomatosis with polyangiitis
What are the top hospitals conducting granulomatosis with polyangiitis research?
When it comes to advancing the understanding and treatment of granulomatosis with polyangiitis, several top hospitals are leading the way. In Philadelphia, the University of Pennsylvania has four active clinical trials dedicated to this rare condition characterized by inflammation in blood vessels. Over the years, they have conducted a total of 15 trials since their first recorded investigation in 2006. Moving westward to Rochester, Minnesota, we find Mayo Clinic Rochester making significant contributions as well. They currently have two ongoing trials for granulomatosis with polyangiitis and started their journey in researching this disease just six years ago in 2015.
Meanwhile, its counterpart Mayo Clinic located also situated at Rochester holds similar records; conducting around eleven complete investigations till-date whereas simultaneously running two active ones related with said condition from getting their earliest trial documented back during turn of century i.e.,2000.However not being too far behind is National Jewish Health situated within Denver who have had earlier ventures only accomplished a couple tests specifically on granulomatosis with polyangiitis along timeline starting from year 2006 but continuing forward into present-day having yet another pair underway presently aiming make stride further still lastly though relatively smaller scale University Kansas Medical Center rather new participant into field played crucial part embarking upon these endeavors ten years prior when they initiated recording ground-breaking experimentations surrounding aforementioned ailment during year2010.
These esteemed hospitals embody dedication and innovation as they strive to improve outcomes for patients diagnosed with granulomatosis with polyangiitis through cutting-edge research and clinical trials. Their collective efforts bring hope for better treatments and ultimately a brighter future for those affected by this challenging disease
Which are the best cities for granulomatosis with polyangiitis clinical trials?
When it comes to granulomatosis with polyangiitis clinical trials, several cities have emerged as leaders in research and development. Philadelphia, Pennsylvania, currently has 6 active trials focusing on treatments like Obinutuzumab, Depemokimab, and Trimethoprim Sulfamethoxazole. Rochester, Minnesota follows closely behind with 5 ongoing studies investigating similar interventions such as Obinutuzumab and Naltrexone Hydrochloride. Denver, Colorado also contributes to the advancement of treatment options with its 3 active trials exploring Open-Label and Depemokimab interventions. Additionally, Toronto, Ontario offers individuals access to 3 active trials studying treatments like Depemokimab and Abatacept alongside low-dose Prednisone. Lastly,Nashville,Tennessee conducts 2 active trials evaluating Depemokimab and Abatacept therapies for granulomatosis with polyangiitis patients. These cities pave the way for progress in understanding this complex disease while offering hope for improved outcomes through innovative clinical trials.
Which are the top treatments for granulomatosis with polyangiitis being explored in clinical trials?
Granulomatosis with polyangiitis (GPA) is a complex condition that requires ongoing research and development of effective treatments. Currently, several promising options are being explored in clinical trials to combat GPA. These include obinutuzumab, depemokimab, trimethoprim sulfamethoxazole, and naltrexone hydrochloride. While each treatment option has only one active trial and one all-time GPA trial under its belt, they offer hope for improved outcomes for patients suffering from this challenging disease. With continued research and evaluation in the coming years, these treatments may pave the way for better management strategies against granulomatosis with polyangiitis.
What are the most recent clinical trials for granulomatosis with polyangiitis?
Recent clinical trials offer hope and potential breakthroughs for individuals living with granulomatosis with polyangiitis (GPA). Notably, obinutuzumab has shown promise in Phase 2 studies as a potential treatment option. Another trial investigated the effectiveness of depemokimab in Phase 3, aiming to provide valuable insights into its efficacy for GPA patients. Additionally, trimethoprim sulfamethoxazole has been examined in both Phase 1 and Phase 2 trials, shedding light on its potential benefits. Furthermore, naltrexone hydrochloride has been explored as a treatment option during Phase 2 investigations. While these clinical trials are still ongoing or recently completed, they hold great promise for improving outcomes and quality of life for those affected by GPA.
What granulomatosis with polyangiitis clinical trials were recently completed?
Recently completed clinical trials have made significant strides in the understanding and treatment of granulomatosis with polyangiitis. Notably, a trial sponsored by Genentech investigated the use of Rituximab as a potential therapy for this condition. Another study, led by Johns Hopkins University School of Medicine, examined the safety and efficacy of Mepolizumab in treating granulomatosis with polyangiitis. These recent advancements underscore ongoing efforts to improve outcomes for individuals affected by this challenging disease.