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Mechanical Ventilation

PAV+ ventilation strategy for Acute Respiratory Failure (PROMIZING Trial)

N/A

Waitlist Available

Led By Karen J Bosma

Research Sponsored by Lawson Health Research Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 14, 21 and 28 days post randomization

Awards & highlights

PROMIZING Trial Summary

This trial found that for patients requiring mechanical ventilation, PAV+ resulted in a shorter duration of time spent on mechanical ventilation than PSV.

Eligible Conditions

Acute Respiratory Failure
Critically Ill Patients

PROMIZING Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 14, 21 and 28 days post randomization

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~14, 21 and 28 days post randomization

This trial's timeline: 3 weeks for screening, Varies for treatment, and 14, 21 and 28 days post randomization for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Time from randomization to successful liberation from invasive mechanical ventilation.

Secondary outcome measures

Cumulative dose of narcotics (converted to morphine equivalents); benzodiazepines (converted to midazolam equivalents); propofol, and dexmedetomidine

Mortality

Number of patients and number of patient-days receiving any antipsychotic medication

+7 more

Other outcome measures

Subgroup analyses based on (b) failing an SBT prior to randomization

Subgroup analyses based on (c) failed extubation prior to randomization

Subgroup analyses based on (d) mild vs. moderate vs. severe frailty

+1 more

PROMIZING Trial Design

2Treatment groups

Active Control

Group I: PAV+ ventilation strategyActive Control1 Intervention

The intervention is a PAV+ ventilation strategy, designed to adjust the level of support (gain) to target a predefined range of respiratory muscle pressure.

Group II: PSV ventilation strategyActive Control1 Intervention

The control is the standard of care PSV ventilation strategy, designed to adjust the level of support according to usual clinical parameters.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV

1,344 Previous Clinical Trials

26,452,842 Total Patients Enrolled

MedtronicIndustry Sponsor

606 Previous Clinical Trials

828,090 Total Patients Enrolled

Canadian Critical Care Trials GroupOTHER

30 Previous Clinical Trials

227,710 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the upper limit of participants for this medical experiment?

"Affirmative. Clinicaltrials.gov details that this experiment, which was listed on September 14th 2016, is actively recruiting 558 participants from 11 different sites."

Answered by AI

How many venues are being utilized for the management of this clinical trial?

"At present, the trial is recruiting from 11 different sites. These locations are spread out with some popular examples being Kingston, Montréal and London. To reduce travel time requirements for participants, it is encouraged to choose a site in close proximity when signing up."

Answered by AI

Has the enrollment period for this experiment concluded?

"Affirmative. Records held on clinicaltrials.gov suggest that this medical trial, which was posted on September 14th 2016, is actively looking for participants. 558 volunteers need to be recruited from 11 different research facilities."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study

2016. "Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02447692.