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Mechanical Ventilation

Volume Control mode for Respiratory Failure (MODE Trial)

N/A
Waitlist Available
Led By Kevin P. Seitz, MD, MSc
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up enrollment to 72 hours
Awards & highlights

MODE Trial Summary

This trial will compare 3 modes of providing mechanical ventilation to critically ill adults to determine which has the best outcome.

Eligible Conditions
  • Respiratory Failure

MODE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~enrollment to 72 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and enrollment to 72 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Ventilator-free days (VFDs) to day 28 after enrollment
Other outcome measures
Adherence to study mode in first 3 days (Feasibility Outcome)
Delirium and coma free days to day 28 (Exploratory Efficacy and Safety Outcome)
Exhaled tidal volumes above target range (Exploratory Efficacy and Safety Outcome)
+12 more

MODE Trial Design

3Treatment groups
Active Control
Group I: Volume Control modeActive Control1 Intervention
During invasive mechanical ventilation in a study location, Volume Control will be used as the mode for continuous mandatory ventilation.
Group II: Pressure Control modeActive Control1 Intervention
During invasive mechanical ventilation in a study location, Pressure Control will be used as the mode for continuous mandatory ventilation.
Group III: Adaptive Pressure Control modeActive Control1 Intervention
During invasive mechanical ventilation in a study location, Adaptive Pressure Control will be used as the mode for continuous mandatory ventilation.

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
856 Previous Clinical Trials
671,626 Total Patients Enrolled
4 Trials studying Respiratory Failure
3,008 Patients Enrolled for Respiratory Failure
Kevin P. Seitz, MD, MScPrincipal InvestigatorClinical Fellow

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are included in the current trial?

"That is correct. According to clinicaltrials.gov, this medical study, which was first posted on November 1st 2022, is actively enrolling patients. The study seeks a total of 606 participants from one location."

Answered by AI

Is enrollment for this research endeavor accepting participants at present?

"Clinicaltrials.gov lists this study as actively enrolling participants, with the date of initial posting being November 1st 2022 and most recent revision on November 8th 2022."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Mode Of Ventilation During Critical IllnEss Pilot Trial
Kevin P Seitz 2022. "Mode Of Ventilation During Critical IllnEss Pilot Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05563779.
~234 spots leftby Apr 2025
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