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Procedure

Ventilatory Strategy for Atelectasis

N/A
Waitlist Available
Led By Roberto F Casal
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year
Awards & highlights

Study Summary

This trial compares VESPA to standard mechanical ventilation for preventing atelectasis during bronchoscopy under general anesthesia.

Who is the study for?
This trial is for adults who need a bronchoscopy with ultrasound for lung issues, and have had a chest CT scan in the last 4 weeks. It's not for those with diaphragmatic paralysis, excessive air retention, large lung bullae, ascites, history of spontaneous pneumothorax, pregnant women or if there are significant changes or masses in certain areas of their lungs.Check my eligibility
What is being tested?
The VESPA trial is testing whether a new ventilatory strategy can prevent atelectasis (lung collapse) better than standard mechanical ventilation during bronchoscopy under general anesthesia in patients with lung disease.See study design
What are the potential side effects?
Potential side effects may include discomfort from the different ventilation method and risks typically associated with general anesthesia such as nausea, sore throat, dizziness and rarely more serious complications like respiratory problems.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Presence or absence of atelectasis for each patient
Presence or absence of atelectasis within each of the 6 bronchial segments
Presence or absence of new atelectasis for each segment
Secondary outcome measures
Bronchoscopy-induced complications
Ventilatory strategy to prevent atelectasis (VESPA)-induced complications

Side effects data

From 2020 Phase 2 trial • 28 Patients • NCT02230189
5%
Pregnancy identified during study enrollment
5%
Increased systolic blood pressure post-bronchoscopy
5%
Respiratory infection post-bronchoscopy
100%
80%
60%
40%
20%
0%
Study treatment Arm
Allergic Asthmatics(AA)
Allergic Non-Asthmatics(ANA)
Non-Allergic Non-Asthmatics(NANA)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Group II (VESPA)Experimental Treatment2 Interventions
Patients receive anesthesia using a longer breathing tube called an endotracheal tube and then undergo standard of care bronchoscopy.
Group II: Group I (conventional mechanical ventilation)Active Control2 Interventions
Patients receive anesthesia using a standard short breathing tube called LMA and then undergo standard of care bronchoscopy.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Anesthesia Procedure
2020
N/A
~80
Bronchoscopy
2002
Completed Phase 2
~2300

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,966 Previous Clinical Trials
1,804,701 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,654 Previous Clinical Trials
40,933,073 Total Patients Enrolled
Roberto F CasalPrincipal InvestigatorM.D. Anderson Cancer Center
3 Previous Clinical Trials
128 Total Patients Enrolled

Media Library

Anesthesia Procedure (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04311723 — N/A
Lung Disease Research Study Groups: Group I (conventional mechanical ventilation), Group II (VESPA)
Lung Disease Clinical Trial 2023: Anesthesia Procedure Highlights & Side Effects. Trial Name: NCT04311723 — N/A
Anesthesia Procedure (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04311723 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
Texas
How old are they?
18 - 65
What site did they apply to?
M D Anderson Cancer Center
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
ChestJournal
Ventilatory Strategy to Prevent Atelectasis During Bronchoscopy Under General Anesthesia
Salahuddin, Moiz, Mona Sarkiss, Ala-Eddin S. Sagar, Ioannis Vlahos, Christopher H. Chang, Archan Shah, Bruce F. Sabath, et al.. 2022. “Ventilatory Strategy to Prevent Atelectasis During Bronchoscopy Under General Anesthesia”. Chest. Elsevier BV. doi:10.1016/j.chest.2022.06.045.
clinicaltrials.govStudy
Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial
2020. "Ventilatory Strategy for the Prevention of Atelectasis During Bronchoscopy Under General Anesthesia, VESPA Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04311723.
~17 spots leftby Apr 2025
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