CLINICAL TRIAL

Arthroscopic Irrigation and Debridement for Arthritis

Recruiting · Any Age · All Sexes · El Paso, TX

This study is evaluating whether arthroscopic management of septic arthritis in the native knee resulted in a lower number of surgeries and a shorter length of stay compared to open arthrotomy.

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About the trial for Arthritis

Eligible Conditions
Arthritis · Septic Arthritis · Arthritis, Infectious

Treatment Groups

This trial involves 2 different treatments. Arthroscopic Irrigation And Debridement is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Open Arthrotomy with irrigation and debridement
PROCEDURE
Arthroscopic Irrigation and Debridement
PROCEDURE
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.

Eligibility

This trial is for patients born any sex of any age. There are 3 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Adults (>18 years old)
Have a diagnosis of septic arthritis of the native knee (synovial WBC >50k or acrystalline elevated synovial WBC >25,000 with high clinical suspicion)
Willingness to participate in the study
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: Through anticipated follow up period of 3 month post operative appointment.
Screening: ~3 weeks
Treatment: Varies
Reporting: Through anticipated follow up period of 3 month post operative appointment.
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: Through anticipated follow up period of 3 month post operative appointment..
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Arthroscopic Irrigation and Debridement will improve 2 primary outcomes and 3 secondary outcomes in patients with Arthritis. Measurement will happen over the course of Through time period of initial admission (days; expected under 14 days).

Hospital length of stay
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
The total number of days in which the patient is initially admitted in order to obtain appropriate clinical response and resultant discharge on outpatient antibiotics.
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
Number of surgeries to obtain lasting clinical resolution
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
The total number of surgeries performed during initial admission in order to obtain appropriate clinical response and resultant discharge on outpatient antibiotics.
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
Post Operative Pain Scores
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
Daily morning and afternoon visual analogue scale reported by nursing staff. This value is reported on a scale of 0-10; a score of 0 indicates no pain while 10 indicates unbearable pain
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
Post Operative Opioid Use
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
All patients will have post operative pain medications which are to be utilized in a step wise manner for treating their pain. For example, if they are in minimal pain they will be given tylenol whereas unbearable pain will be treated with opioid analgesics. The average total post-operative opioid usage during initial admission will be reported as total morphine milligram equivalent.
THROUGH TIME PERIOD OF INITIAL ADMISSION (DAYS; EXPECTED UNDER 14 DAYS)
Lysholm Knee Scale
THROUGH ANTICIPATED FOLLOW UP PERIOD OF 3 MONTH POST OPERATIVE APPOINTMENT.
The Lysholm score is a 100-point scoring system for examining a patient's knee-specific symptoms including mechanical locking, instability, pain, swelling, stair climbing, and squatting. The scoring is between 0-100 points. A score of <65 indicates poor knee function, 65-83 indicates fair knee function, 84-94 indicates a fair outcome, and 95-100 indicates excellent knee function. This scoring system will be obtained at 2 week, 6 week, and 3 months.
THROUGH ANTICIPATED FOLLOW UP PERIOD OF 3 MONTH POST OPERATIVE APPOINTMENT.

Who is running the study

Principal Investigator
M. W.
Matthew Wells, Principal Investigator
Texas Tech University Health Sciences Center, El Paso

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can arthritis be cured?

This article reviews the treatments and studies that have been done that have had positive results in regards to arthritis and arthritis symptoms. The authors conclude that in regards to their arthritis symptoms, it is crucial to find the right medication or treatment plan for the right patient.

Anonymous Patient Answer

What are common treatments for arthritis?

Common treatments for arthritis include nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, corticosteroid injections, hydroxychloroquine, methotrexate, cyclosporine, leflunomide, infliximab, etanercept, tocilizumab, tofacitinib, rituximab, adalimumab, natalizumab, rituximab, and rituximab combined with tumor necrosis factor (TNFR) blockers such as etanercept, tocilizumab, and tranilizumab.

Anonymous Patient Answer

What are the signs of arthritis?

Although symptoms of arthritis are not unique to arthritis, certain symptoms are more specific for arthritis than systemic disease such as elevated erythrocyte sedimentation rate is a common indicator of systemic disease in inflammatory arthritic conditions. Other erythrocyte indices are not specific for arthritis.

Anonymous Patient Answer

What is arthritis?

Arthritis affects over 100 million people in the UK. It results in joint pain, stiffness, and, if overlooked, long-term joint loss. People oftentimes live in isolation, so often try different remedies rather than a proper diagnosis. The NHS has made treatments available free of charge. Arthritis can be a debilitating disease with many possible treatments including NSAIDs and disease-modifying antirheumatic drugs.

Anonymous Patient Answer

What causes arthritis?

Overall, the studies indicated that a range of factors could play a role, either in the development of, or in the exacerbation of, rheumatoid arthritis. More research is needed, however, to better understand the role of specific exposures. Such factors could include certain viruses, microbes, or certain chemicals encountered in the environment.

Anonymous Patient Answer

How many people get arthritis a year in the United States?

About 10 million Americans will be diagnosed with some form of arthritis. As with any other disease, the frequency of arthritis can vary from person to person.

Anonymous Patient Answer

Have there been any new discoveries for treating arthritis?

Although many new drugs show promise in preliminary studies with regard to their efficacy as treatments for arthritis, few have been approved for use in humans. At present only MTX and tocilizumab are approved for treatment of erosive and proliferative RA.

Anonymous Patient Answer

How serious can arthritis be?

There seems to be a clear division between the attitudes of people to the seriousness of arthritis. Those with debilitating symptoms seem to find it harder to manage their illness. This may affect the quality of life. To help these people in the longer term it may be helpful to have a clear and supportive plan for the management of their arthritis.

Anonymous Patient Answer

Have there been other clinical trials involving arthroscopic irrigation and debridement?

A trial that evaluates long-term analgesic effect and treatment outcome that is as effective as arthroscopic irrigation and debridement would be difficult to design. Clinical trial design should take into account factors such as treatment duration, patient selection, and duration of onset of symptoms. Randomized controlled trials with patients without baseline differences may be the best tool for assessing the efficacy of irrigation and debridement. summary: Results from a recent paper finds that irrigation and debridement does not decrease pain.

Anonymous Patient Answer

What does arthroscopic irrigation and debridement usually treat?

The study showed no correlation between the arthroscopic lavage/debridement and the success of the treatment in relieving the pain or improving quality of life. There was a trend towards a reduction in the inflammatory markers and improvements in general and joint function. Arthroscopic lavage/debridement is useful for patients with the [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis), but not for the degenerative arthritis. However, for both conditions, the pain and function improved drastically after the lavage/debridement irrespective of the underlying cause of arthritis.

Anonymous Patient Answer

Does arthroscopic irrigation and debridement improve quality of life for those with arthritis?

Improved joint function and increased functional activity could be detected in patients with anaerobic infections following arthroscopic knee lavage. However, a randomized, placebo-controlled trial is needed to further investigate the potential benefits of arthroscopic lavage on quality of life outcomes. This trial was registered at the Australian New Zealand Clinical Trials Registry (ACTRN1261100121483) as ISRCTN43096853.

Anonymous Patient Answer

Has arthroscopic irrigation and debridement proven to be more effective than a placebo?

A placebo in this case was not an effective intervention. In addition to being effective on the symptoms and function, the arthroscopic procedure may help the patients' joints function better long term. Considering the patients' ability and preferences (for example: pain reduction, better quality of life etc.), arthroscopic irrigation and debridement seems to be an option.

Anonymous Patient Answer
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