Behavioural Intervention

Active TBS for Opioid Use Disorder

Centre for Addiction and Mental Health, Toronto, Canada
Targeting 2 different conditionsActive TBS +1 moreN/ARecruitingLed by Daphne Voineskos, MD, PhDResearch Sponsored by Centre for Addiction and Mental Health

Study Summary

This trial will compare the effects of a real vs. fake brain stimulation treatment on patients with both opioid addiction and depression who are experiencing suicidal thoughts.

Eligible Conditions
  • Opioid Use Disorder
  • Depression

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have been diagnosed with Opioid Dependence and Major Depressive Disorder (MDD) through a specific kind of interview called MINI.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline, to end of tbs treatment course (4 weeks), and at 1 month follow up
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline, to end of tbs treatment course (4 weeks), and at 1 month follow up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Scale for Suicidal Ideation Remission
Secondary outcome measures
Mental Depression
Change in Columbia - Suicide Severity Rating Scale Change
Change in Scale for Suicidal Ideation Change
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active TBSExperimental Treatment1 Intervention
Daily, 4-week, 5-days per week treatment sessions, each consisting of: First, intermittent TBS (iTBS) over the L-DLPFC: triplet 50 Hz bursts, repeated at 5 Hz, 2 s on and 8 s off, (600 pulses per session, total duration of 3 min 9 s), then continuous TBS (cTBS) over the R-DLPFC as 40 s uninterrupted bursts (600 pulses). Intensity at 120% resting motor threshold (RMT).
Group II: Sham TBSPlacebo Group1 Intervention
Daily, 4-week, 5-days per week treatment sessions. The sham coil will generate auditory and somatosensory (vibratory) stimuli identical to the active stimulation.

Find a site

Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor
340 Previous Clinical Trials
81,085 Total Patients Enrolled
The Physicians' Services Incorporated FoundationOTHER
161 Previous Clinical Trials
26,805 Total Patients Enrolled
Daphne Voineskos, MD, PhDPrincipal Investigator
Clinician Scientist, Psychiatrist

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being enrolled in the research project?

"Affirmative. records demonstrate that the trial, first posted on March 1st 2022, is actively recruiting patients with 20 volunteers needed from one medical facility."

Answered by AI

Are new participants being welcomed into this medical experiment?

"Affirmative. According to the database, this trial is still recruiting patients and has been since March 1st 2022 when it was initially listed. As of October 17th 2021, 20 volunteers are needed from a single study site."

Answered by AI
~8 spots leftby Sep 2024