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Behavioural Intervention

Active TBS for Opioid Use Disorder

N/A

Waitlist Available

Led By Daphne Voineskos, MD, PhD

Research Sponsored by Centre for Addiction and Mental Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up change from baseline, to end of tbs treatment course (4 weeks), and at 1 month follow up

Awards & highlights

Study Summary

This trial will compare the effects of a real vs. fake brain stimulation treatment on patients with both opioid addiction and depression who are experiencing suicidal thoughts.

Eligible Conditions

Opioid Use Disorder
Depression

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, after tbs treatment course (4 weeks), and at 1 month follow up

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, after tbs treatment course (4 weeks), and at 1 month follow up

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, after tbs treatment course (4 weeks), and at 1 month follow up for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Scale for Suicidal Ideation Remission

Secondary outcome measures

Mental Depression

Change in Columbia - Suicide Severity Rating Scale Change

Change in Scale for Suicidal Ideation Change

+2 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active TBSExperimental Treatment1 Intervention

Daily, 4-week, 5-days per week treatment sessions, each consisting of: First, intermittent TBS (iTBS) over the L-DLPFC: triplet 50 Hz bursts, repeated at 5 Hz, 2 s on and 8 s off, (600 pulses per session, total duration of 3 min 9 s), then continuous TBS (cTBS) over the R-DLPFC as 40 s uninterrupted bursts (600 pulses). Intensity at 120% resting motor threshold (RMT).

Group II: Sham TBSPlacebo Group1 Intervention

Daily, 4-week, 5-days per week treatment sessions. The sham coil will generate auditory and somatosensory (vibratory) stimuli identical to the active stimulation.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Active TBS

2022

N/A

~10

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor

356 Previous Clinical Trials

81,434 Total Patients Enrolled

The Physicians' Services Incorporated FoundationOTHER

162 Previous Clinical Trials

26,745 Total Patients Enrolled

Daphne Voineskos, MD, PhDPrincipal InvestigatorClinician Scientist, Psychiatrist

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are being enrolled in the research project?

"Affirmative. Clinicaltrials.gov records demonstrate that the trial, first posted on March 1st 2022, is actively recruiting patients with 20 volunteers needed from one medical facility."

Answered by AI

Are new participants being welcomed into this medical experiment?

"Affirmative. According to the clinicaltrials.gov database, this trial is still recruiting patients and has been since March 1st 2022 when it was initially listed. As of October 17th 2021, 20 volunteers are needed from a single study site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

rTMS for Suicidality in Opioid Use Disorder

2022. "rTMS for Suicidality in Opioid Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04785456.