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Transcranial Magnetic Stimulation

cTBS followed by iTBS for Depression

N/A

Waitlist Available

Led By Daniel M. Blumberger, MD

Research Sponsored by Centre for Addiction and Mental Health

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after 4 or 6 weeks

Awards & highlights

Study Summary

This trial compares two types of brain stimulation to see if one is more effective than the other in treating major depression.

Eligible Conditions

Depression

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after 4 or 6 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after 4 or 6 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and after 4 or 6 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change on the Montgomery Asberg Depression Rating Scale (MADRS)

Secondary outcome measures

Remission on the MADRS

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Bilateral Theta Burst StimulationExperimental Treatment1 Intervention

cTBS followed by iTBS. continuous theta burst stimulation (cTBS) of the right DLPFC for 600 pulses followed by intermittent theta burst stimulation (iTBS) of the left DLPFC for 600 pulses. Treatment will occur 5 times per week for 4 to 6 weeks.

Group II: Convential Sequential Bilateral rTMSActive Control1 Intervention

LFR followed by HFL. 1 Hz stimulation of the right DLPFC for 600 pulses followed by 10 Hz stimulation of the left DLPFC for 3000 pulses (4 seconds on 26 seconds off for 75 trains). Treatment will occur 5 times per week for 4 to 6 weeks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

cTBS followed by iTBS

2016

N/A

~170

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Find a Location

Who is running the clinical trial?

Centre for Addiction and Mental HealthLead Sponsor

354 Previous Clinical Trials

80,957 Total Patients Enrolled

84 Trials studying Depression

18,964 Patients Enrolled for Depression

University Health Network, TorontoOTHER

1,468 Previous Clinical Trials

484,356 Total Patients Enrolled

52 Trials studying Depression

11,863 Patients Enrolled for Depression

Daniel M. Blumberger, MDPrincipal InvestigatorCAMH

Media Library

Depression Clinical Trial 2023: cTBS followed by iTBS Highlights & Side Effects. Trial Name: NCT02998580 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there currently an opportunity for individuals to join this research effort?

"The clinicaltrials.gov portal reveals that recruitment for this trial has been suspended since February 10th 2022, though it was initially posted in December 1st 2016. Thankfully, there are currently 1296 other medical studies seeking volunteers at the present moment."

Answered by AI

Recent research and studies

JAMA PsychiatryJournal

Effectiveness of Standard Sequential Bilateral Repetitive Transcranial Magnetic Stimulation Vs Bilateral Theta Burst Stimulation in Older Adults with Depression

Blumberger, Daniel M., Benoit H. Mulsant, Kevin E. Thorpe, Shawn M. McClintock, Gerasimos N. Konstantinou, Hyewon H. Lee, Sean M. Nestor, et al.. 2022. “Effectiveness of Standard Sequential Bilateral Repetitive Transcranial Magnetic Stimulation Vs Bilateral Theta Burst Stimulation in Older Adults with Depression”. JAMA Psychiatry. American Medical Association (AMA). doi:10.1001/jamapsychiatry.2022.2862.

clinicaltrials.govStudy

Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression

Daniel Blumberger 2016. "Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02998580.