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Ketamine Hydrochloride for Opioid Use Disorder

Phase 2
Waitlist Available
Led By Jennifer Jones, MD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up outcomes will be cumulatively assessed from the time that the first participant is screened through the time that the last participant is enrolled. estimated time frame of: 23 months.
Awards & highlights

Study Summary

This trial is examining whether ketamine could improve treatment outcomes for people with opioid addiction and depression when used with buprenorphine. If you enroll, participation will last about 8 weeks.

Eligible Conditions
  • Opioid Use Disorder
  • Depression
  • Opioid Addiction

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~outcomes will be cumulatively assessed from the time that the first participant is screened through the time that the last participant is enrolled. estimated time frame of: 23 months.
This trial's timeline: 3 weeks for screening, Varies for treatment, and outcomes will be cumulatively assessed from the time that the first participant is screened through the time that the last participant is enrolled. estimated time frame of: 23 months. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Percentage of Individuals Completing Informed Consent
Percentage of Individuals Completing the Full Protocol
Secondary outcome measures
Change in Depression Severity

Side effects data

From 2020 Phase 4 trial • 75 Patients • NCT03156504
1%
Lightheadedness with low blood pressure
1%
Pump Malfunction
1%
PTSD
100%
80%
60%
40%
20%
0%
Study treatment Arm
Ketamine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Group A (Ketamine)Experimental Treatment1 Intervention
Group II: Group B (Placebo)Placebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketamine Hydrochloride
2018
Completed Phase 4
~910

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
932 Previous Clinical Trials
7,394,369 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,467 Previous Clinical Trials
2,619,102 Total Patients Enrolled
Jennifer Jones, MDPrincipal Investigator - Medical University of South Carolina
Texas Health Harris Methodist Continued Care Hospital, Texas Health Harris Methodist Heart Center
Medical University Of South Carolina College Of Medicine (Medical School)

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Ketamine Hydrochloride lead to serious health complications?

"There is some data supporting Ketamine Hydrochloride's safety, but none suggesting that it is an effective medication. It received a score of 2."

Answered by AI

How many individuals are participating in this experiment?

"The clinical trial is seeking 30 participants and is actively recruiting, according to the information available on clinicaltrials.gov. The study was posted on December 17th, 2020 and updated January 7th, 2022."

Answered by AI

Are people with the right medical conditions currently able to enroll in this trial?

"The clinical trial is still active and looking for participants, as the information on clinicaltrials.gov indicates. The study was first posted on December 17th 2020, with the most recent update being January 7th of 2022. They are recruiting 30 individuals from 1 location."

Answered by AI

Does this research allow for patients that are older than 70 years of age?

"The age range of 18 to 65 is an inclusion criterion for this particular study. There are 516 other trials available for minors and 1883 studies that senior citizens can participate in."

Answered by AI

How can I sign up for the clinical trial?

"This study is looking for 30 patients that have depression and use opioids. The trial requirements are as follows: Subjects must be considered to have treatment-refractory MDD as evidenced by failure or only partial response to treatment with at least two standard of care pharmacotherapy antidepressants., Have used opioids illicitly at least once in the past month., Between the ages of 18 to 65 years old., Able to provide informed consent., Meet DSM-5 criteria for Major Depressive Disorder, without psychotic features., Score at least 20 on the Montgomery-Asberg Depression Rating Scale., Fulfill a minimum of 4 of 11 current opioid use disorder"

Answered by AI

Who else is applying?

What state do they live in?
Arizona
Wisconsin
North Carolina
Other
How old are they?
65+
18 - 65
What site did they apply to?
Medical University of South Carolina
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

I have done some research on ketamine clinics that treat addiction but unfortunately my insurance will not cover any of these treatments.
PatientReceived no prior treatments
Desperate for relief after 13+ miserable years without joy or happiness or pleasure or love of any kind. I'm in need of help badly. Or i don't know what to do.
PatientReceived 1 prior treatment

How responsive is this trial?

Most responsive sites:
  1. Medical University of South Carolina: < 48 hours
Typically responds via
Email
Average response time
  • < 2 Days
~5 spots leftby Apr 2025