Accelerated TBS for Suicidality
Trial Summary
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators.
What data supports the effectiveness of this treatment for suicidality?
Research shows that accelerated intermittent Theta Burst Stimulation (iTBS) can significantly decrease suicide risk in patients with treatment-resistant depression, with effects lasting up to a month. However, the decrease in suicide risk was observed regardless of whether the active or sham treatment was used, suggesting a strong placebo effect.12345
Is accelerated Theta Burst Stimulation (TBS) safe for humans?
How does accelerated Theta Burst Stimulation (TBS) differ from other treatments for suicidality?
Accelerated Theta Burst Stimulation (TBS) is unique because it involves a rapid series of magnetic pulses applied to the brain over a short period, specifically targeting the left dorsolateral prefrontal cortex, which is thought to influence mood and suicidal thoughts. Unlike traditional treatments, it is administered intensively over just a few days and has shown a decrease in suicide risk that lasts up to a month, even in patients who do not respond to depression treatments.12345
What is the purpose of this trial?
This is a pilot study to analyze the benefit of accelerated continuous Transcranial magnetic stimulation for inpatient subjects suffering with suicidal ideation. This study will enroll 40 inpatient subjects recruited from the Resnick Neuropsychiatric hospital. Subjects will be blinded and randomized to active or sham TMS treatment and will receive up to 5 assigned treatments per day. Subjects will also be asked to complete mood surveys throughout their participation. Participation in this study will last 7-10 days depending on scheduling.
Eligibility Criteria
This trial is for inpatients aged 18-65 with major depressive disorder (MDD) and current suicidal thoughts, who have never had TMS treatment before. They must pass a safety questionnaire to participate. People with borderline personality disorder, past brain stimulation treatments, schizophrenia spectrum disorders, epilepsy or other major neurological issues can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive up to 5 sessions of accelerated continuous theta-burst stimulation (acTBS) daily for 4-6 days
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- accelerated Thetaburst stimulation
- Sham Comparator
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor