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ATTR-CM positive for Heart Failure

N/A
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Left ventricular ejection fraction (LVEF) >40%.
Prior clinical history of myocardial infarction, CABG or multi-vessel obstructive coronary disease (>50% stenosis of ≥2 epicardial coronary arteries).
Must not have
Diagnosis of heart failure with reduced ejection fraction (HFrEF) (EF ≤40%).
Timeline
Screening 3 weeks
Treatment Varies
Follow Up visit 1(baseline) through follow-up visit 1 (day 44)
Awards & highlights

Study Summary

This trial is a global, multi-center study to find how many people have a heart condition called ATTR-CM.

Eligible Conditions
  • Transthyretin Amyloid Cardiomyopathy
  • Heart Failure

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Answer YES if you do NOT have any significant valvular disorder in your heart
Select...
Answer YES if you do NOT have a history of myocardial infarction or bypass graft?
Select...
Are you currently receiving treatment for your Heart Failure?
Select...
Answer YES if you do NOT have any significant psychiatric conditions or suicidal ideation.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
Have you been diagnosed with heart failure?

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~visit 1(baseline) through follow-up visit 1 (day 44)
This trial's timeline: 3 weeks for screening, Varies for treatment, and visit 1(baseline) through follow-up visit 1 (day 44) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Estimate of global prevalence of ATTR-CM in HFpEF patients.
Secondary outcome measures
Estimate of prevalence of ATTR-CM within region, age and gender
New York Heart Association (NYHA) Classification of HFpEF participants diagnosed with ATTR-CM compared with HFpEF participants negative for ATTR-CM
Nt-proBNP results of HFpEF participants diagnosed with ATTR-CM compared with HFpEF participants negative for ATTR-CM
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: ATTR-CM positiveExperimental Treatment1 Intervention
Participants diagnosed with ATTR-CM by scintigraphy
Group II: ATTR-CM negativeExperimental Treatment1 Intervention
Participants who are scintigraphy negative for ATTR-CM
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Scintigraphy
2020
N/A
~70

Find a Location

Who is running the clinical trial?

PfizerLead Sponsor
4,570 Previous Clinical Trials
10,915,413 Total Patients Enrolled
20 Trials studying Heart Failure
6,906 Patients Enrolled for Heart Failure
Pfizer CT.gov Call CenterStudy DirectorPfizer
3,476 Previous Clinical Trials
8,091,631 Total Patients Enrolled
9 Trials studying Heart Failure
5,933 Patients Enrolled for Heart Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many sites is the research trial being administered across?

"14 centres are currently enrolling patients into this trial, which include Ottawa, Topeka and Saint-Jean-sur-Richelieu. To alleviate travel burdens for those who partake in the study, it is recommended that participants select a site closest to their current location."

Answered by AI

Is this research initiative actively seeking to enroll participants?

"Clinicaltrials.gov data reveals that this experiment is in its recruitment phase as of November 17th 2022, when it was last updated. Initially posted on December 30 2020, the study invites volunteers to participate."

Answered by AI

How many trial participants are being monitored for this experiment?

"This clinical trial requires 2000 eligible individuals to register. Patients can sign up at various medical centres, such as the University of Ottawa Heart Institute in Ottawa, Ontario and Cotton O'Neil Heart Center in Topeka, Kansas."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
Connecticut
Other
Florida
What site did they apply to?
WakeMed Health and Hospital
Cotton O'Neil Heart Center
Innova Pharma Research
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
1
0
2

Why did patients apply to this trial?

I take entresto but i think is no working. I’d like to learn more about improving my EF.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. Innova Pharma Research: < 48 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Global Prevalence of ATTR-CM in Participants With HFpEF
2020. "Global Prevalence of ATTR-CM in Participants With HFpEF". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04424914.
~74 spots leftby May 2025
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