CAD-CAM Dental Crowns for Restorative Dentistry

Overseen By Dennis J. Fasbinder, DDS

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Ivoclar Vivadent AG

Disqualifiers: Devital teeth, Endodontic treatment, Untreated dental disease, Pregnant, Allergies, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 1 day

80 Participants Needed

Trial Summary

What is the purpose of this trial?

CAD-CAM crowns made of lithium disilicate are placed in patients by using either a dual-curing adhesive or a self-adhesive luting material in combination with total etch/universal bonding agent.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Lithium Disilicate Crowns?

Research shows that lithium disilicate crowns, made using CAD-CAM technology, are strong and look natural, making them a good choice for dental restorations. Studies have shown they perform well over time, with high patient satisfaction and durability. ^{1 2 3 4 5}

Is it safe to use CAD-CAM lithium disilicate dental crowns?

Research suggests that lithium disilicate crowns are generally safe, but there may be some biological risks associated with their composition and processing. No major safety concerns have been reported in the studies, but further research on their biomechanical behavior is needed. ^{3 6 7 8 9}

How is the treatment of lithium disilicate crowns unique compared to other dental crown treatments?

Lithium disilicate crowns are unique because they are made using CAD-CAM technology, which allows for precise and efficient milling, resulting in highly esthetic and strong restorations that can be created chair-side. This digital approach offers a modern alternative to traditional methods, providing a quicker and more predictable outcome. ^{3 10 11 12 13}

Research Team

Dennis J. Fasbinder, DDS

Principal Investigator

University of Michigan School of Dentistry, Department of Cariology, Restorative Sciences & Endodontics

Eligibility Criteria

This trial is for adults over 18 with a cavity or damaged tooth needing a full crown on certain teeth. They must have healthy, symptom-free teeth with at least one opposing and adjacent tooth in good condition. Pregnant women, those allergic to study materials, or unable to attend follow-ups are excluded.

Inclusion Criteria

I am 18 years old or older.

I have at least one cavity or a need for tooth repair on an upper or lower back tooth.

I need a full crown due to significant tooth damage or decay.

Exclusion Criteria

I have dead or sensitive teeth.

I cannot come back for follow-up visits.

I have had treatments to protect the nerve inside my tooth.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

CAD-CAM crowns made of lithium disilicate are placed in patients using either a dual-curing adhesive or a self-adhesive luting material

1 day

1 visit (in-person)

Follow-up

Participants are monitored for post-operative sensitivity and quality of crowns

4 weeks

Weekly feedback

Long-term follow-up

Participants are assessed for quality criteria of crowns over time

5 years

Treatment Details

Interventions

• Lithium Disilicate Crowns

Trial Overview The study tests lithium disilicate crowns placed using two different adhesives: dual-curing adhesive or self-adhesive luting material combined with total etch/universal bonding agent. It aims to determine the best method for attaching these types of dental crowns.

Participant Groups

Group I: Crowns self-adhesively cemented Experimental Treatment 1 Intervention

Group 1 receives crowns with an occlusal thickness of 1.5 mm and luted with a self-adhesive, self-curing resin cement (SpeedCem Plus, Ivoclar Vivadent AG).

Group II: Crowns adhesively luted Experimental Treatment 1 Intervention

Group 2 receives crowns with an occlusal thickness of 1.2 mm delivered with a dual-curing resin cement (Variolink Esthetic (DC),Ivoclar Vivadent AG).

Who Is Running the Clinical Trial?

Ivoclar Vivadent AG

Lead Sponsor

Trials

38

Recruited

2,400+

Findings from Research

A study involving 214 patients showed that chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns have a high cumulative survival rate of 91.06% after 36 months, indicating their durability and effectiveness as a dental restoration option.

The crowns demonstrated excellent esthetic outcomes, with high scores for color, shape, and chewing ability throughout the 36-month follow-up, and their survival rate was not significantly influenced by factors such as gender, age, or pulp condition.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

[Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns]. Chen, YJ., Yao, Y., Luo, AX.[2021]

References

1. China pubmed.ncbi.nlm.nih.gov

[Clinical performance of chairside monolithic lithium disilicate glass-ceramic CAD-CAM crowns]. [2021]

2. Switzerland pubmed.ncbi.nlm.nih.gov

Clinical Outcomes and Predictors of Satisfaction in Patients with Improved Lithium Disilicate All-Ceramic Crowns. [2018]

3. United States pubmed.ncbi.nlm.nih.gov

CAD/CAM and lithium disilicate: an anterior esthetic case study. [2013]

4. Germany pubmed.ncbi.nlm.nih.gov

Retrospective survival analysis of 110 lithium disilicate crowns with feather-edge marginal preparation. [2021]

5. United States pubmed.ncbi.nlm.nih.gov

Clinical performance of CAD-CAM crowns provided by predoctoral students at the University of Toronto. [2022]

6. Korea (South) pubmed.ncbi.nlm.nih.gov

Early complications and performance of 327 heat-pressed lithium disilicate crowns up to five years. [2020]

7. United States pubmed.ncbi.nlm.nih.gov

Evaluation of the marginal and internal gaps of partially crystallized versus fully crystallized zirconia-reinforced lithium silicate CAD-CAM crowns: An in vitro comparison of the silicone replica technique, direct view, and 3-dimensional superimposition analysis. [2023]

8. England pubmed.ncbi.nlm.nih.gov

In vitro cytotoxic response to lithium disilicate dental ceramics. [2008]

9. United States pubmed.ncbi.nlm.nih.gov

Fit and fatigue behavior of CAD-CAM lithium disilicate crowns. [2023]

10. Egypt pubmed.ncbi.nlm.nih.gov

A Step-by-Step Conservative Approach for CAD-CAM Laminate Veneers. [2020]

11. United States pubmed.ncbi.nlm.nih.gov

Marginal adaptation of CAD-CAM and heat-pressed lithium disilicate crowns: A systematic review and meta-analysis. [2023]

12. United States pubmed.ncbi.nlm.nih.gov

Marginal and internal fit of pressed lithium disilicate inlays fabricated with milling, 3D printing, and conventional technologies. [2018]

13. Germany pubmed.ncbi.nlm.nih.gov

Can lithium disilicate ceramic crowns be fabricated on the basis of CBCT data? [2019]