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Autonomic Function Testing for Heart Condition

N/A

Waitlist Available

Led By C. Noel Bairey Merz, M.D.

Research Sponsored by Cedars-Sinai Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours

Awards & highlights

Study Summary

This trial is investigating the role of the autonomic nervous system in microvascular coronary dysfunction, a condition that affects small arteries in the heart and causes chest pain. They will recruit 100 participants over the next five years.

Who is the study for?

This trial is for women over 18 with microvascular coronary dysfunction (MCD) and persistent chest pain, but no obstructive coronary artery disease. They must be able to consent and not have conditions like severe asthma, heart block, or metal devices in the chest that would exclude them from certain tests.Check my eligibility

What is being tested?

The study investigates how the autonomic nervous system responds to stress in women with MCD. It involves non-invasive tests like RESPeRATE breathing, SPECT cardiac scans, mental stress testing, PAT testing, and HRV measurement to assess cardiovascular reactivity.See study design

What are the potential side effects?

Potential side effects are minimal as most interventions are non-invasive monitoring techniques. However, there may be discomfort or minor risks associated with the SPECT scan due to radiation exposure and possible allergic reactions to injected tracers.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cardiovascular Reactivity (CVR)

Trial Design

3Treatment groups

Experimental Treatment

Group I: normal reference controlsExperimental Treatment5 Interventions

40 normal reference controls subjects Visits 1 and 2

Group II: abnormal CRTExperimental Treatment5 Interventions

40 subjects with microvascular coronary dysfunction (MCD) defined as abnormal CRT. Visits 1, 2, and 3

Group III: Cardiac Syndrome XExperimental Treatment5 Interventions

20 subjects with symptoms and normal stress tests, no MCD. Visits 1 and 2

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Cedars-Sinai Medical CenterLead Sponsor

499 Previous Clinical Trials

164,752 Total Patients Enrolled

6 Trials studying Nephrotic Syndrome

592 Patients Enrolled for Nephrotic Syndrome

C. Noel Bairey Merz, M.D.Principal InvestigatorCedars-Sinai Medical Center

2 Previous Clinical Trials

188 Total Patients Enrolled

Puja Mehta, M.D.Principal InvestigatorEmory University

Media Library

Heart Rate Variability (HRV) Clinical Trial Eligibility Overview. Trial Name: NCT01568177 — N/A

Nephrotic Syndrome Research Study Groups: abnormal CRT, Cardiac Syndrome X, normal reference controls

Nephrotic Syndrome Clinical Trial 2023: Heart Rate Variability (HRV) Highlights & Side Effects. Trial Name: NCT01568177 — N/A

Heart Rate Variability (HRV) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01568177 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the enrollment period for this trial still open?

"Clinicaltrials.gov accounts for this clinical trial no longer seeking volunteers, with the initial posting being on February 1st 2011 and the last edit occurring July 20th 2022. Fortunately, there are still 29 other medical trials actively recruiting participants at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Cardiac Autonomic Function in Women With Microvascular Coronary Dysfunction

Noel Bairey Merz 2011. "Cardiac Autonomic Function in Women With Microvascular Coronary Dysfunction". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01568177.