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Behavioural Intervention

Mindfulness + Cognitive Training for Healthy Aging (MATILDA Trial)

N/A
Waitlist Available
Led By Paulina Skolasinska, MS
Research Sponsored by The University of Texas at Dallas
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 9-10 weeks (includes baseline assessment, training, and post-training assessment)
Awards & highlights

MATILDA Trial Summary

This trial will test if meditation & cognitive game can improve brain function & cognition in older adults. Participants will be assessed before & after 8-week (~20 hr) training of at-home meditation & cognitive game.

Who is the study for?
This trial is for right-handed individuals aged 65-85 who learned English before age 5, have at least a high school education, and can undergo MRI scans without issues like claustrophobia or metal implants. They should not be pregnant, have significant health problems like heart disease or CNS trauma, substance abuse issues, or severe vision impairments.Check my eligibility
What is being tested?
The study tests if mindfulness meditation combined with cognitive games (MM+HighC) improves brain function in healthy older adults. Participants will practice meditation and play games on a tablet for about 20 hours over eight weeks and get cognitive and neuroimaging assessments before and after the intervention.See study design
What are the potential side effects?
Since this trial involves non-invasive practices such as mindfulness meditation and cognitive training games, side effects are minimal to none. However, discomfort from staying still during MRI scans may occur.

MATILDA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~9-10 weeks (includes baseline assessment, training, and post-training assessment)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 9-10 weeks (includes baseline assessment, training, and post-training assessment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in composite score of overall cognition
Change in task-related functional connectivity of the DMN
Secondary outcome measures
Change in task-related functional connectivity of the cognitive networks
Change in the Composite Score of Psychosocial Functioning
Change in white matter structural connectivity
Other outcome measures
Change in composite score of episodic memory
Change in composite score of executive control
Change in composite score of processing speed
+4 more

MATILDA Trial Design

1Treatment groups
Experimental Treatment
Group I: Combined mindfulness meditation and cognitive trainingExperimental Treatment1 Intervention
Participants train at home for 20 hours over 8 weeks, splitting the time between mindfulness meditation and cognitive training. Participants train for 30 minutes per day, for 5 days a weeks on a provided tablet computer. The participants are to keep a paper log of dates and durations. The mindfulness meditation portion of the training is a commercially available mobile app. Participants listen to guided meditations and follow the instructions. The program includes common mindfulness meditation exercises such as body scan or breath awareness. The cognitive training portion of the intervention uses a highly demanding attentional control training program BirdWatch game (BWGU). BWGU is a "gamified" n-back paradigm where participants randomly switch the focus of attention to update or maintain an adaptively growing set of bird stimuli in their working memory and are sometimes required to inhibit their response.

Find a Location

Who is running the clinical trial?

The University of Texas at DallasLead Sponsor
58 Previous Clinical Trials
106,259 Total Patients Enrolled
Paulina Skolasinska, MSPrincipal InvestigatorThe University of Texas at Dallas
Chandramallika Basak, PhDStudy DirectorThe University of Texas at Dallas
1 Previous Clinical Trials
75 Total Patients Enrolled

Media Library

MM+HighC (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT05974605 — N/A
Healthy Aging Research Study Groups: Combined mindfulness meditation and cognitive training
Healthy Aging Clinical Trial 2023: MM+HighC Highlights & Side Effects. Trial Name: NCT05974605 — N/A
MM+HighC (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05974605 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research initiative open to individuals above the age of 40?

"Applicants for this medication trial must be between the ages of 65 and 85. There are two studies dedicated to those under 18, as well as 52 studies focusing on individuals above that age range."

Answered by AI

How many volunteers have been recruited for this experiment?

"Affirmative. The information accessible on clinicaltrials.gov verifies that this scientific investigation, which was first posted on March 17th 2022, is actively recruiting participants. 16 individuals have to be recruited from 1 medical centre."

Answered by AI

Does this trial currently accept enrollments?

"The trial's presence on clinicaltrials.gov indicates that recruitment is still underway, and the original posting date was March 17th 2022 with recent updates taking place in July 26 2023."

Answered by AI

Is there an opportunity for me to participate in this research?

"Eligible patients must demonstrate healthy aging and fall within the ages of 65 to 85. 16 participants are needed for this clinical trial."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Mindfulness and Attention Training Intervention to Lower Distractibility in Aging
Chandramallika Basak 2022. "Mindfulness and Attention Training Intervention to Lower Distractibility in Aging". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05974605.
~5 spots leftby Apr 2025
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