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Cognitive & Physical Interventions for Healthy Aging (SAGE Trial)
N/A
Waitlist Available
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be 65 or older
Have a score within 2 standard deviations (SD) of the age-appropriate mean on the short form of the Boston Naming Test
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of study - 5 weeks post-baseline
Awards & highlights
SAGE Trial Summary
This trial found that structured intervention programs can help improve cognitive processing and performance in older adults. There is evidence that neuroplasticity occurs in individuals over the age of 65.
Who is the study for?
The SAGE trial is for individuals aged 65 or older with good cognitive health, at least 8 years of education, and fluency in English. Participants must score well on tests assessing memory and language skills, have normal vision and hearing, be physically able to engage in exercise, and not suffer from severe depression or major psychiatric disorders.Check my eligibility
What is being tested?
This study examines the effects of structured programs like physical activity, cognitive stimulation, mindfulness training versus no intervention (control group) on improving cognitive function in seniors. It also looks for signs of brain changes that suggest learning and adaptation (neuroplasticity).See study design
What are the potential side effects?
Since this trial involves non-invasive interventions such as exercise and mental training rather than medication, side effects are minimal but may include typical exercise-related risks like muscle strain or fatigue.
SAGE Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 65 years old or older.
Select...
My language skills test score is close to average for my age.
SAGE Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ end of study - 5 weeks post-baseline
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of study - 5 weeks post-baseline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Cambridge Neuropsychological Test Automated Battery (CANTAB), a computerized assessment of cognitive functions
Categorical Fluency
Controlled Oral Word Association Test (COWAT)
+3 moreSAGE Trial Design
4Treatment groups
Active Control
Placebo Group
Group I: Physical Exercise Training Using an Interactive Video PlatformActive Control1 Intervention
Subjects will participate in a structured physical exercise training program that aims to progressively increase their level of activity over the 5 week training period.
Group II: Cognitive Training using CogmedActive Control1 Intervention
Subjects will complete computerized cognitive training with varying degrees of difficulty over 5 weeks.
Group III: Awareness (mindfulness) trainingActive Control1 Intervention
Subject participate in mindfulness training. The meditation and tasks will become increasingly more self-directed over the 5 weeks; the degree of guidance will decrease to keep the subjective effort approximately constant and moderately challenging through the 5 weeks.
Group IV: Low Level of Cognitive Training Using the Cogmed ProgramPlacebo Group1 Intervention
Subjects will complete the same computerized training as the active cognitive arm over the course of 5 weeks, but the main difference is that for the control group task difficulty will remain at the same low starting level, rather than increasing over time.
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Who is running the clinical trial?
Brigham and Women's HospitalLead Sponsor
1,598 Previous Clinical Trials
11,462,266 Total Patients Enrolled
1 Trials studying Healthy Aging
60 Patients Enrolled for Healthy Aging
Linnaeus UniversityOTHER
26 Previous Clinical Trials
14,235 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- My language test score is close to average for my age.I have no history of major brain diseases or serious mental health issues.I am 65 years old or older.My language skills test score is close to average for my age.I do not have heart or lung conditions that stop me from doing physical exercises.To be eligible for this scholarship, you must have ≥ 8 years of education.I am 65 years old or older.Score within 2 standard deviations of the average score for someone your age on the Logical Memory Subtest of the Wechsler Memory Scale-Third Edition.
Research Study Groups:
This trial has the following groups:- Group 1: Physical Exercise Training Using an Interactive Video Platform
- Group 2: Low Level of Cognitive Training Using the Cogmed Program
- Group 3: Cognitive Training using Cogmed
- Group 4: Awareness (mindfulness) training
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who else is applying?
What state do they live in?
Rhode Island
Massachusetts
How old are they?
18 - 65
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
What site did they apply to?
Brigham and Women's Hospital
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