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CPE for Taste Disturbance
N/A
Waitlist Available
Led By Beverly J Tepper, Ph.D.
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
PROP high-sensitive individuals (PROP super-tasters; homozygous dominant for TAS2R38 gene)
PROP insensitive individuals (PROP non-tasters; homozygous recessive for TAS2R38 gene)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline measure 3 days after control intervention; post intervention measure 11 days after experimental intervention
Awards & highlights
Study Summary
This trial explores the role of tannins and salivary proteins in the perception of astringency and their effects on human health. It suggests that individual differences in this sensation may have a genetic basis.
Who is the study for?
This trial is for people who are either very sensitive or not sensitive to a taste-related gene (PROP), have good oral health, and recently saw a dentist. Smokers, pregnant women, those with taste/smell issues or oral piercings, and anyone on medication (except birth control) can't join.Check my eligibility
What is being tested?
The study is testing how plain water compared to CPE (a type of tannin) affects the feeling of dryness in the mouth and changes in taste. It aims to understand individual differences in tasting bitterness related to genetics and oral health.See study design
What are the potential side effects?
Since this trial involves consuming plain water or CPE which are common dietary substances, significant side effects are not expected. However, some individuals might experience temporary changes in taste perception.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a super-taster based on my TAS2R38 gene test.
Select...
I cannot taste certain bitter flavors due to my genetics.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline measure 3 days after control intervention; post intervention measure 11 days after experimental intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline measure 3 days after control intervention; post intervention measure 11 days after experimental intervention
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Change from Baseline Composition of Oral Microbiome after 11 days
Change from Baseline Levels of Salivary Proteins after 11 days
Change from Baseline Taste and Flavor Intensity Ratings after 11 days
Trial Design
2Treatment groups
Experimental Treatment
Group I: PROP super-taster subjectsExperimental Treatment2 Interventions
This arm will comprise of PROP super-taster subjects. Subjects will use a cranberry-derived oral rinse twice a day for 11 days following a 3-day plain water-rinse period.
Group II: PROP non-taster subjectsExperimental Treatment2 Interventions
This arm will comprise of PROP non-taster subjects. Subjects will use a cranberry-derived oral rinse twice a day for 11 days following a 3-day plain water-rinse period.
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Who is running the clinical trial?
Rutgers, The State University of New JerseyLead Sponsor
429 Previous Clinical Trials
64,183 Total Patients Enrolled
Beverly J Tepper, Ph.D.Principal InvestigatorRutgers University
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You are a smoker.You have piercings in your mouth.I am taking medications other than birth control.I regularly see a dentist or oral health professional.I am generally healthy and maintain good oral hygiene.I recently had a dental cleaning by a professional.You do not currently have any issues with your teeth or mouth.I am a super-taster based on my TAS2R38 gene test.I have problems with my sense of taste or smell.I have a medium sensitivity to bitter tastes due to my genetics.I cannot taste certain bitter flavors due to my genetics.
Research Study Groups:
This trial has the following groups:- Group 1: PROP non-taster subjects
- Group 2: PROP super-taster subjects
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who is likely to benefit most from participation in this research study?
"For qualification, the trial requires applicants to have dry mouth and be between 18-50 years old. 60 participants are needed for this study's enrollment process."
Answered by AI
Does this trial impose an age limit for participants?
"This clinical experiment is open to those who are between 18 and 50 years of age."
Answered by AI
To what extent is the participant pool of this trial expanding?
"Indeed, the information on clinicaltrials.gov indicates that this investigation is currently enrolling participants. This trial was first made available to the public on October 28th 2022 and has since been updated as of April 5th 2023. Approximately 60 individuals must be recruited from one site in total."
Answered by AI
Is enrollment in this clinical trial currently accessible?
"Confirmed. This experiment is presently recruiting participants as indicated on clinicaltrials.gov, with the study being initially posted in October 28th 2022 and most recently edited in April 5th 2023."
Answered by AI
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