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Inhibition Group for Obesity (STS Trial)

Q: To what extent is the population size of this clinical trial?

<p>Affirmative. Clinicaltrials.gov attests to this clinical trial's ongoing recruitment efforts, which began on April 24th 2019 and were most recently updated on April 26 2021. Right now, 80 patients are needed for the study at one site.</p>

Q: Does this research investigation admit seniors for participation?

<p>To enrol in this clinical trial, individuals must be between 21 and 40 years of age. For those under 18 or over 65, 202 and 596 trials respectively are available for them to consider.</p>

N/A

Waitlist Available

Led By Marta Y Pepino, PhD

Research Sponsored by University of Illinois at Urbana-Champaign

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 hours after drinking a glucose load

Awards & highlights

STS Trial Summary

This trial will help researchers understand how low-calorie sweeteners may affect metabolism and health.

STS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 hours after drinking a glucose load

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 hours after drinking a glucose load

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 hours after drinking a glucose load for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Plasma C-Peptide

Plasma Glucose

Plasma Insulin

+1 more

STS Trial Design

2Treatment groups

Experimental Treatment

Group I: Stimulation GroupExperimental Treatment4 Interventions

Randomly selected habitual and non habitual LCS consumers will be assessed on three different oral glucose tolerance test conditions (i.e. Control - Stimulation, Experimental I- Stimulation, Experimental II -Stimulation). A separate visit will evaluate their sweet taste perception and preferences (Sensory evaluation).

Group II: Inhibition GroupExperimental Treatment4 Interventions

Randomly selected habitual and non habitual LCS consumers will be assessed on three different oral glucose tolerance test conditions (i.e. Control - Inhibition, Experimental I- Inhibition, Experimental II- Inhibition). A separate visit will evaluate their sweet taste perception and preferences (Sensory evaluation).

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Washington University School of MedicineOTHER

1,931 Previous Clinical Trials

2,299,629 Total Patients Enrolled

77 Trials studying Obesity

13,737 Patients Enrolled for Obesity

University of Illinois at Urbana-ChampaignLead Sponsor

188 Previous Clinical Trials

37,255 Total Patients Enrolled

22 Trials studying Obesity

2,410 Patients Enrolled for Obesity

Marta Y Pepino, PhDPrincipal InvestigatorUniversity of Illinois at Urbana-Champaign

2 Previous Clinical Trials

138 Total Patients Enrolled

2 Trials studying Obesity

138 Patients Enrolled for Obesity

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this trial seeking new participants at present?

"Per clinicaltrials.gov, this trial has been open to participants since April 24th 2019 and was recently modified on the 26th of April 2021 - it is still actively recruiting individuals for participation."

Answered by AI

Do I meet the qualifications to participate in this research project?

"This research project is looking to recruit 80 individuals within the age range of 21 and 40 years old, who are clinically obese. Furthermore, they must be habitual (>5 diet sodas per week) or non-habitual (≤1 diet soda or 1 packet of LCS per week), not severely insulin resistant (HOMA-IR2 < 2.6), from any race/ethnicity background, with a BMI between 30 and 40 kg/m2."

Answered by AI

To what extent is the population size of this clinical trial?

"Affirmative. Clinicaltrials.gov attests to this clinical trial's ongoing recruitment efforts, which began on April 24th 2019 and were most recently updated on April 26 2021. Right now, 80 patients are needed for the study at one site."

Answered by AI

Does this research investigation admit seniors for participation?

"To enrol in this clinical trial, individuals must be between 21 and 40 years of age. For those under 18 or over 65, 202 and 596 trials respectively are available for them to consider."

Answered by AI

Recent research and studies

Journal of Biological ChemistryJournal

Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste

Jiang, Peihua, Meng Cui, Baohua Zhao, Zhan Liu, Lenore A. Snyder, Lumie M.J. Benard, Roman Osman, Robert F. Margolskee, and Marianna Max. 2005. “Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste”. Journal of Biological Chemistry. Elsevier BV. doi:10.1074/jbc.m414287200.

Clinical NutritionJournal

The Functional Involvement of Gut-expressed Sweet Taste Receptors in Glucose-stimulated Secretion of Glucagon-like Peptide-1 (GLP-1) and Peptide YY (PYY)

Steinert, R.E., A.C. Gerspach, H. Gutmann, L. Asarian, J. Drewe, and C. Beglinger. 2011. “The Functional Involvement of Gut-expressed Sweet Taste Receptors in Glucose-stimulated Secretion of Glucagon-like Peptide-1 (GLP-1) and Peptide YY (PYY)”. Clinical Nutrition. Elsevier BV. doi:10.1016/j.clnu.2011.01.007.

Food and Chemical ToxicologyJournal

The FEMA GRAS Assessment of Phenethyl Alcohol, Aldehyde, Acid, and Related Acetals and Esters Used as Flavor Ingredients

Adams, T.B., S.M. Cohen, J. Doull, V.J. Feron, J.I. Goodman, L.J. Marnett, I.C. Munro, et al.. 2005. “The FEMA GRAS Assessment of Phenethyl Alcohol, Aldehyde, Acid, and Related Acetals and Esters Used as Flavor Ingredients”. Food and Chemical Toxicology. Elsevier BV. doi:10.1016/j.fct.2004.11.013.

The American Journal of Clinical NutritionJournal