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Radiation Therapy

VMAT for Brain Tumor

N/A

Waitlist Available

Led By Alan M Nichol, MD

Research Sponsored by British Columbia Cancer Agency

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year post-treatment

Awards & highlights

Study Summary

This trial will use a novel radiotherapy technique, called volumetric modulated arc therapy (VMAT), to treat patients with brain metastases. VMAT allows for delivery of both a standard radiation dose to the whole brain, as well as a higher radiation dose to the brain metastases at the same time. The study will assess the effectiveness of using VMAT in treating brain metastases, and examine its potential side-effects.

Eligible Conditions

Metastatic Brain Tumors

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year post-treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year post-treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year post-treatment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

3 month treatment response of metastases evaluated using contrast-enhanced MRI scan of brain

Secondary outcome measures

1-year brain control of metastases evaluated with contrast-enhanced MRI scan of brain

1-year local control of treated metastases evaluated with contrast-enhanced MRI scan of brain

Both acute neurological toxicity (within 3 months of treatment) and late neurological toxicity (beyond 3 months of treatment

+3 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Whole brain radiotherapyExperimental Treatment1 Intervention

whole brain radiotherapy (WBRT) and a simultaneous integrated boost (SIB) using volumetric modulated arc therapy

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

British Columbia Cancer AgencyLead Sponsor

171 Previous Clinical Trials

90,451 Total Patients Enrolled

Alan M Nichol, MDPrincipal InvestigatorBritish Columbia Cancer Agency

1 Previous Clinical Trials

1,514 Total Patients Enrolled

Media Library

Volumetric Modulated Arc Therapy (VMAT) (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01046123 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this experiment actively recruiting participants?

"According to the information posted on clinicaltrials.gov, this investigation is not presently seeking candidates. Initially published in 2010 and last updated in 2021, there are still 887 other trials that have open enrollment for volunteers."

Answered by AI

What are the minimum qualifications for enrollment in this clinical experiment?

"This clinical trial seeks to recruit 60 individuals whose age is between 18 and 100. All participants must satisfy the following qualifications: they should have a malignancy diagnosed within the past 5 years; 1-10 brain metastases, with the largest's diameter not exceeding 3 cm; KPS score of 70 or higher; no neurologic instability that requires corticosteroids use; disease outside of their cranium adequately managed (estimated life expectancy 6 months); be available for follow up examinations and imaging tests; prior cranial surgery allowed if applicable."

Answered by AI

Are participants below the age of fifty-five eligible for this research endeavor?

"Individuals 18 years of age and above, up to a maximum of 100, may be eligible for this clinical study in accordance with the stated inclusion requirements."

Answered by AI

Recent research and studies

Radiation OncologyJournal

Patients with Pretreatment Leukoencephalopathy and Older Patients Have More Cognitive Decline After Whole Brain Radiotherapy

Chan, Matthew, David Ferguson, Elaine Ni Mhurchu, Ren Yuan, Lovedeep Gondara, Michael McKenzie, Robert Olson, et al.. 2020. “Patients with Pretreatment Leukoencephalopathy and Older Patients Have More Cognitive Decline After Whole Brain Radiotherapy”. Radiation Oncology. Springer Science and Business Media LLC. doi:10.1186/s13014-020-01717-x.

International Journal of Radiation Oncology*Biology*PhysicsJournal

Volumetric Radiosurgery for 1 to 10 Brain Metastases: A Multicenter, Single-arm, Phase 2 Study

Nichol, Alan, Roy Ma, Fred Hsu, Lovedeep Gondara, Hannah Carolan, Robert Olson, Devin Schellenberg, et al.. 2016. “Volumetric Radiosurgery for 1 to 10 Brain Metastases: A Multicenter, Single-arm, Phase 2 Study”. International Journal of Radiation Oncology*biology*physics. Elsevier BV. doi:10.1016/j.ijrobp.2015.10.017.

clinicaltrials.govStudy

Volumetric Modulated Arc Therapy (VMAT) for Brain Metastases

Alan Nichol 2010. "Volumetric Modulated Arc Therapy (VMAT) for Brain Metastases". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01046123.

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