Best 10 Denver Clinical Trials [2022 Studies]

Atezolizumab (MPDL3280A), An Engineered Anti-PD-L1 Antibodyfor Carcinoma, Non-Small-Cell Lung

Rochester, MN

18+

All Sexes

This study is evaluating whether a drug may help treat lung cancer.

Phase-Based Estimates

Talazoparib With Enzalutamidefor mCRPC

This study is evaluating whether a drug called talazoparib may help men with prostate cancer.

Phase-Based Estimates

Palbociclibfor Breast Cancer

Primary Objectives: Dose Escalation: To assess the incidence rate of dose-limiting toxicity (DLT) and to determine the maximum tolerated dose (MTD) as well as the recommended dose (RD) of amcenestrant administered as monotherapy and in combination with palbociclib To assess the incidence rate of DLT and determine the RD of everolimus or abemaciclib in combination with the selected amcenestrant dose for the combination therapy Safety Run-In: - To confirm the RD of amcenestrant in combination with alpelisib Dose Expansion: Antitumor activity using objective response rate (ORR) Overall safety profile of amcenestrant administered in combination with palbociclib, alpelisib, everolimus, and abemaciclib Secondary Objectives: Overall safety profile of amcenestrant monotherapy and in combination Pharmacokinetic (PK) profile of amcenestrant administered as monotherapy or in combination and PK profile of palbociclib, alpelisib, everolimus and abemaciclib Antitumor activity using ORR, the clinical benefit rate (CBR) and progression free survival (PFS) Time to first tumor response Residual ER availability with positron emission tomography (PET) scan [(18)F] fluoroestradiol (18F-FES) uptake with increasing doses of amcenestrant Food effect on PK of amcenestrant Potential induction/inhibition effect of amcenestrant on cytochrome P450 (CYP) 3A using 4b-OH cholesterol

Phase-Based Estimates

Autologous Hematopoietic Stem Cell Transplantationfor Lymphoma, Mantle-Cell

This study is evaluating whether rituximab, a monoclonal antibody, may help treat mantle cell lymphoma.

Phase-Based Estimates

KPT-8602for Multiple Myeloma

This study is evaluating whether a new drug can be used to treat cancer.

Phase-Based Estimates

Crizotinibfor Carcinoma, Non-Small-Cell Lung

This study is evaluating whether a drug called crizotinib may help treat patients with non-small cell lung cancer.

Phase-Based Estimates

NOVOCART 3Dfor Articular Cartilage of the Femoral Condyle Between 2-6cm2

This study is evaluating whether a new treatment for knee cartilage defects is safe and effective.

Phase-Based Estimates

Orvepitant Maleatefor Fibrosis

ORV-PF-01 is a two way, placebo controlled, cross-over study, to evaluate the effect of two doses of orvepitant on cough in patients with IPF.

Phase-Based Estimates

Sacituzumab Govitecan-hziyfor Breast Cancer

This is a Phase 2, multicenter, open-label, single arm study evaluating the safety and efficacy of trilaciclib administered prior to sacituzumab govitecan-hziy in patients with unresectable, locally advanced or metastatic triple-negative breast cancer (TNBC) who received at least 2 prior treatments, at least 1 in the metastatic setting.

Phase-Based Estimates

TAK-500for Squamous Cell Cancer

This study is about TAK-500, given either alone or with pembrolizumab, in adults with select locally advanced or metastatic solid tumors. The aims of the study are: to assess the safety profile of TAK-500 when given alone and when given with pembrolizumab. to assess the effects of TAK-500, when given alone and when given with pembrolizumab, on adults with locally advanced or metastatic solid tumors. Participants may receive TAK-500 for up to 1 year. Participants may continue with their treatment if they have continuing benefit and if this is approved by their study doctor. Participants who are receiving TAK-500 either alone or with pembrolizumab will continue with their treatment until their disease progresses or until they or their study doctor decide they should stop this treatment.

Phase-Based Estimates

VX-121/TEZ/D-IVAfor Cystic Fibrosis

This study is evaluating whether a drug called VX-121 can improve lung function in people with cystic fibrosis.

Phase-Based Estimates

Benralizumabfor Bronchiectasis

This study is evaluating whether benralizumab can reduce exacerbation rates in patients with non-cystic fibrosis bronchiectasis.

Phase-Based Estimates

Ligelizumabfor Peanut Allergies

This is a 52-week, Phase 3 multi-center, randomized, double-blind and placebo-controlled study to assess the safety and clinical efficacy of two dosing regimens of ligelizumab (240 mg and 120 mg) subcutaneous injection every 4 weeks (SCq4w) in participants with a medically confirmed diagnosis of IgE-mediated peanut allergy.

Phase-Based Estimates

Semagludtidefor Alzheimer Disease

This study is done to find out whether the medicine, semaglutide, has a positive effect on early Alzheimer's disease. Participants will either get semaglutide or placebo (a "dummy" medicine which does not contain any study medicine) - which treatment participants get is decided by an equal chance. The study will last for up to 173 weeks (about 3 years and 4 months). Participants will have 17 clinic visits and 1 phone call with the study doctor. The study includes various tests and scans. At 10 of the clinic visits participants will have blood samples taken. Participants must have a study partner, who is willing to take part in the study. Women cannot take part if pregnant, breastfeeding or plan to become pregnant during the study period. A cerebrospinal fluid (CSF) sub-study will be performed as a part of the study. The sub-study will be performed on a selection of sites based on their experience with CSF sampling and willingness to participate in this sub-study. The endpoints related to this sub-study are exploratory only.

Phase-Based Estimates

Relugolix Combination Therapyfor Leiomyoma

This study is evaluating whether a combination of two drugs may help prevent pregnancy.

Phase-Based Estimates

Vadadustatfor Kidney Diseases

This study is evaluating whether a drug may help treat anemia in individuals who are receiving hemodialysis.

Phase-Based Estimates

Dupilumab SAR231893for Disease

Phase-Based Estimates

Sotorasibfor Carcinoma, Non-Small-Cell Lung

This study is evaluating whether a drug called AMG 510 can help treat non-small cell lung cancer.

Phase-Based Estimates

Brensocatib 25 Mgfor Bronchiectasis

This study is evaluating whether a drug may help reduce the number of times a person with COPD has an exacerbation.

Phase-Based Estimates

Niraparibfor Hypersensitivity

This study is evaluating whether a combination of two drugs may help treat prostate cancer.

Phase-Based Estimates

Epcoritamabfor Lymphoma

This study is evaluating whether a new drug may help treat Non-Hodgkin Lymphoma.

Phase-Based Estimates

5-azacitidinefor Syndrome

This study is evaluating whether a combination of two drugs may be more effective than either drug alone.

Phase-Based Estimates

Fluorouracilfor Cancer of Colon

This study is evaluating whether a blood test can predict whether a patient with stage IIA colon cancer will benefit from chemotherapy.

Phase-Based Estimates

CYT-0851for Oral Squamous Cell Carcinoma

This study is evaluating whether a drug may help treat cancer.

Phase-Based Estimates

Wireless Neuromodulationfor Osteoarthritic Knee Pain

This study is evaluating whether active sub-threshold stimulation of the knee joint can help reduce pain in people with chronic knee pain.

Phase-Based Estimates

Niraparibfor Prostatic Cancer, Castration-Resistant

This study is evaluating whether a drug called niraparib may help treat advanced prostate cancer.

Phase-Based Estimates

Ruxolitinib Phosphatefor Leukemia, Myeloid, Chronic-Phase

This study is evaluating whether a combination of drugs may help treat chronic myeloid leukemia.

Phase-Based Estimates

Cabazitaxelfor Prostate Cancer

This study is evaluating whether a combination of drugs may help treat prostate cancer.

Phase-Based Estimates

Nivolumabfor Chordoma

Phase-Based Estimates

Anti-hypertensive Therapyfor Hypertension

This study is evaluating whether a blood pressure treatment strategy during pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults (<140/90 mmHg) compared AC

Phase-Based Estimates

Quality-of-Life Assessmentfor Fallopian Tube Cancer

This study is evaluating whether changes in diet and physical activity can increase the length of survival without the return of cancer.

Phase-Based Estimates

MT-101for Lymphoma

This is a Phase 1/2 study to test the safety, tolerability, and efficacy of the investigational agent MT-101 in patients with Peripheral T cell Lymphoma. MT-101 is made with myeloid cells collected from the patient's blood. The myeloid cells are modified and later infused back into their veins. The modified myeloid cells recognize the tumor cells and are designed to target and kill them.

Phase-Based Estimates

Soticlestatfor Lennox Gastaut Syndrome

This study is evaluating whether soticlestat, when given as add-on therapy, reduces the number of major motor drop seizures in children, teenagers, and adults with Lennox-Gastaut Syndrome.

Phase-Based Estimates

INQOVI (oral Decitabine)for Syndrome

Main objective of this study is to describe and evaluate safety and efficacy of MBG453 (sabatolimab) in combination with FDA approved HMAs of investigator's choice (IV Decitabine or Azacitidine /SC Azacitidine /Oral Decitabine (cedazuridine combination (INQOVI))

Phase-Based Estimates

CTP-543for Alopecia Areata

This study is evaluating whether a drug may help regrow hair in patients with alopecia areata.

Phase-Based Estimates

Radiation Therapyfor Lymphoma

This study is evaluating whether a new type of treatment for primary mediastinal B-cell lymphoma (PMBCL) is better than standard treatment.

Phase-Based Estimates

Abemaciclibfor Breast Cancer

This study is evaluating whether a drug called abemaciclib may help treat breast cancer.

Phase-Based Estimates

TNB-585for Prostate Cancer

This study is evaluating whether a drug may help treat prostate cancer.

Phase-Based Estimates

Pep-Palfor Cancer of Colon

This study is evaluating whether a psychoeducation program can help reduce depressive symptoms in caregivers of cancer patients.

Phase-Based Estimates

VLP-encapsulated TLR9 Agonist CMP-001for Cancer of Skin

This study is evaluating whether a combination of two immunotherapy drugs may help treat melanoma.

Phase-Based Estimates

IV Ganciclovirfor Respiratory Failure

This study is evaluating whether a drug may help improve outcomes for patients with sepsis.

Phase-Based Estimates

BMS-986278for Fibrosis

This study is evaluating whether a drug may help treat lung fibrosis.

Phase-Based Estimates

Dronabinolfor Pain, Postoperative

This study is evaluating whether cannabis may help reduce narcotic use in individuals undergoing knee surgery.

Phase-Based Estimates

Pembrolizumabfor Carcinoma in Situ

This study is evaluating whether an immunotherapy drug may help treat bladder cancer.

Phase-Based Estimates

TPX-0046for Cancer

This study is evaluating whether a drug which targets a specific gene may help treat cancer.

Phase-Based Estimates

Questionnaire Administrationfor Cancer of Oropharnyx

This study is evaluating whether a reduced dose of radiation therapy and nivolumab may be as effective as standard dose radiation therapy and cisplatin in treating patients with oropharynge

Phase-Based Estimates

CT053for Multiple Myeloma

This study is evaluating whether a type of white blood cell called T-cells may help treat multiple myeloma.

Phase-Based Estimates

Daratumumabfor Multiple Myeloma

This study is evaluating whether a drug may help people with multiple myeloma.

Phase-Based Estimates

CTP-543for Alopecia Areata

This study is evaluating whether a drug may help treat hair loss.

Phase-Based Estimates

Multi-Allergen Oral Immunotherapyfor Hypersensitivity

This study is evaluating whether a drug may help people with peanut allergies eat foods containing peanuts.

Phase-Based Estimates

Pemetrexedfor Lung Cancer

This study is evaluating whether a combination of chemotherapy and immunotherapy may be more effective than chemotherapy alone in treating non-small cell lung cancer.

Phase-Based Estimates

Ipilimumabfor Cancer

This study is evaluating whether the addition of a drug to the treatment of patients with renal cell cancer may improve the effectiveness of the treatment.

Clinical Trials in Denver, CO

View medical research that is recruiting in Denver, Colorado. Filter by phase, distance, and inclusion criteria to find cutting edge treatments & access premium care.

ST-067for Oral Squamous Cell Carcinoma

Selinexorfor Multiple Myeloma

AZD9833for Breast Cancer

ALISfor Infections

Radiopaque Etonogestrel (ENG) Implantfor Contraception

Extended Release Metformin Hydrochloridefor Endometrial Neoplasms

ATH-1017for Alzheimer Disease

Cisplatinfor Lung Cancer

Trastuzumabfor Breast Cancer

Quality-of-Life Assessmentfor Peripheral Nervous System Diseases

REGN5678for Prostate Cancer

Pamrevlumabfor Usual Interstitial Pneumonia

Bardoxolone Methylfor Kidney Diseases

Pembrolizumabfor Melanoma

Cediranib Maleatefor Endometrial Neoplasms

Cisplatinfor Carcinoma, Hepatocellular

Atezolizumab (MPDL3280A), An Engineered Anti-PD-L1 Antibodyfor Carcinoma, Non-Small-Cell Lung

Talazoparib With Enzalutamidefor mCRPC

Palbociclibfor Breast Cancer

Autologous Hematopoietic Stem Cell Transplantationfor Lymphoma, Mantle-Cell

KPT-8602for Multiple Myeloma

Crizotinibfor Carcinoma, Non-Small-Cell Lung

NOVOCART 3Dfor Articular Cartilage of the Femoral Condyle Between 2-6cm2

Orvepitant Maleatefor Fibrosis

Sacituzumab Govitecan-hziyfor Breast Cancer

TAK-500for Squamous Cell Cancer

VX-121/TEZ/D-IVAfor Cystic Fibrosis

Benralizumabfor Bronchiectasis

Ligelizumabfor Peanut Allergies

Semagludtidefor Alzheimer Disease

Relugolix Combination Therapyfor Leiomyoma

Vadadustatfor Kidney Diseases

Dupilumab SAR231893for Disease

Sotorasibfor Carcinoma, Non-Small-Cell Lung

Brensocatib 25 Mgfor Bronchiectasis

Niraparibfor Hypersensitivity

Epcoritamabfor Lymphoma

5-azacitidinefor Syndrome

Fluorouracilfor Cancer of Colon

CYT-0851for Oral Squamous Cell Carcinoma

Wireless Neuromodulationfor Osteoarthritic Knee Pain

Niraparibfor Prostatic Cancer, Castration-Resistant

Ruxolitinib Phosphatefor Leukemia, Myeloid, Chronic-Phase

Cabazitaxelfor Prostate Cancer

Nivolumabfor Chordoma

Anti-hypertensive Therapyfor Hypertension

Quality-of-Life Assessmentfor Fallopian Tube Cancer

MT-101for Lymphoma

Soticlestatfor Lennox Gastaut Syndrome

INQOVI (oral Decitabine)for Syndrome

CTP-543for Alopecia Areata

Radiation Therapyfor Lymphoma

Abemaciclibfor Breast Cancer

TNB-585for Prostate Cancer

Pep-Palfor Cancer of Colon

VLP-encapsulated TLR9 Agonist CMP-001for Cancer of Skin

IV Ganciclovirfor Respiratory Failure

BMS-986278for Fibrosis

Dronabinolfor Pain, Postoperative

Pembrolizumabfor Carcinoma in Situ

TPX-0046for Cancer

Questionnaire Administrationfor Cancer of Oropharnyx

CT053for Multiple Myeloma

Daratumumabfor Multiple Myeloma

CTP-543for Alopecia Areata

Multi-Allergen Oral Immunotherapyfor Hypersensitivity

Pemetrexedfor Lung Cancer

Ipilimumabfor Cancer