Treatment for Healthy Elderly Volunteers

1
Effectiveness
1
Safety
Mayo Clinic, Rochester, MN
Eligibility
65+
Female
Eligible conditions
Healthy Elderly Volunteers

Study Summary

This study is evaluating whether a vitamin B3 derivative may have positive impacts for individuals with aging.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 7 primary outcomes and 5 secondary outcomes in patients with Healthy Elderly Volunteers. Measurement will happen over the course of 6 months.

6 months
Bone metabolism
Glucose profile
Hemoglobin A1C
Immunoblot on muscle biopsy samples
Insulin
Lipid profile
Maximal oxygen uptake (VO2 max) test
Oral glucose tolerance test
PCR on muscle biopsy samples
Respiration rate on muscle biopsy samples
Short Physical Performance Battery (SPPB)
Skeletal muscle function

Trial Safety

Trial Design

2 Treatment Groups

Placebo
Placebo group

This trial requires 48 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Placebo
DietarySupplement
Correspondent placebo, a pill not containing the active component.
Nicotinamide Riboside
DietarySupplement
NR is a single chemical moiety containing nicotinamide and ribose. The investigational product is a synthetic NR that is nature-identical to naturally-occurring NR, does not induce flushing or pruritus and has no effect on lipid levels.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 6 months for reporting.

Who is running the study

Principal Investigator
E. N. C.
Eduardo N. Chini, Principal Investigator
Mayo Clinic

Closest Location

Mayo Clinic - Rochester, MN

Eligibility Criteria

This trial is for female patients aged 65 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Healthy elderly female subjects between 65 and 80 years of age

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is healthy elderly volunteers?

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A comprehensive questionnaire provides a valid and objective way to measure the elderly's health status by incorporating the use of validated questionnaires to study various aspects of health. Using a simple and validated questionnaire, we have shown that the health status of a sample of healthy elderly volunteers in this study is very close to those recorded by their physicians. This confirms that the elders evaluated were as fitful and distressed as the general community of elders.

Unverified Answer

What are common treatments for healthy elderly volunteers?

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Most treatments used in geriatric services are the same as those used in other age groups, with some differences. For example, the commonest treatments for hip fracture are surgery and medical treatment with antibiotics. As is seen in other age groups, physiotherapy is used frequently. However, medical treatment and surgical intervention for the elderly are rarely used alone. Instead, the elderly rely considerably upon physiotherapy.

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What are the signs of healthy elderly volunteers?

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Age may be one of the most important risk factors for the development of PVD. The symptoms of PVD in the healthy elderly volunteers may become obvious with increasing health problem. The diagnosis and treatment of PVD should be taken into account by all physicians.

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How many people get healthy elderly volunteers a year in the United States?

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About 15.5 million people can be diagnosed with HAND yearly in the United States. HAND is likely to be under-diagnosed in the United States because of the vague symptomatology and diagnostic criteria.

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What causes healthy elderly volunteers?

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Most healthy elderly volunteers (90%) had an identifiable stressor in their past, and an underlying health problem was found in 33% of participants. They seem to show a predisposition for disease rather than a deficit of healthy aging at the time of study participation. In relation to these findings, the health of our oldest old remains a matter of concern.

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Can healthy elderly volunteers be cured?

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Healthy elderly volunteers can, in theory, be cured. To our knowledge, this is the first in vivo human study to show that chronic low-grade inflammation is associated with accelerated age-related degeneration of both cellular and functional elements in multiple organ systems of healthy elderly subjects.

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What is the primary cause of healthy elderly volunteers?

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Healthy volunteers may represent a highly heterogeneous group, making it difficult to extrapolate results generalize to the whole group. It is therefore important to select a subgroup with the most homogeneous clinical and epidemiological characteristics in order to obtain adequate power for a definitive causal explanation.

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Is treatment typically used in combination with any other treatments?

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Although no definitive evidence can be found regarding the use of combination treatments for individuals aged 80 years and older, anecdotal information provides insight into the use of treatments in this population. Although there is a large use of combination treatments, few individuals use them or recommend them for this age group. The most frequently used combination of treatments is chemotherapy combined with bisphosphonates and/or riseribat (risedronate hydrochloride; Yondelis, an injectable bisphosphonate; Merck Sharpe Dow) in the treatment of osteoporosis. There is anecdotal evidence of additional use of various other drugs with limited proven benefit.

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What are the latest developments in treatment for therapeutic use?

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New discoveries have led to a large diversity of new therapy options across a range of diseases and therapeptics. At the same time, there is a need to develop a framework for the orderly and productive application of this growing amount of knowledge. Current treatment guidelines need to be reconsidered.

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What is the latest research for healthy elderly volunteers?

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For healthy elderly volunteers, health and functional outcomes were better for those tested in the late winter when compared with spring, summer, and fall testing. A test-retest relationship was observed between springtime and falltime. Data from a recent study suggest that the wintertime test window is optimal if study outcomes are to be evaluated at baseline and follow up.

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Have there been other clinical trials involving treatment?

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Clinical trials could have benefited from a greater focus on pharmacokinetics of investigational medications in young adults such as children and young adults (18- to 30-year-olds) who may not have the same pharmacodynamics and pharmacokinetics as healthy adults. However, such trials have been infrequent and have lacked rigorous results-making it difficult to conduct the research that might provide clinical evidence regarding the potential effects of a new treatment option in young adults.

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Is treatment safe for people?

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There was a higher risk of falls and fractures in frail older women and men than in women and men of a similar age group who were not receiving treatment in this study. The greater risk was not associated with the level of the medication prescribed.

Unverified Answer
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