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Vitamin B3 Derivative
Vitamin B3 Derivative for Aging Effects on Bone and Muscle
N/A
Recruiting
Led By Eduardo N Chini, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Healthy elderly female subjects between 65 and 80 years of age
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
Study Summary
This trial is testing if Nicotinamide Riboside, a vitamin B3 derivative, has any effects on bones, muscles, and metabolism in aging.
Who is the study for?
This trial is for healthy elderly women aged between 65 and 80 who have not been part of another drug study in the last year. They must not have severe kidney, liver, or diabetes issues, nor should they be on certain medications like anticoagulants or steroids.Check my eligibility
What is being tested?
The study is testing whether Nicotinamide Riboside (NR), a form of vitamin B3, can improve bone health, muscle function, and metabolism in older adults. Participants will either receive NR or a placebo to compare effects.See study design
What are the potential side effects?
While specific side effects are not listed here, potential risks may include typical reactions to supplements such as digestive discomfort or allergic reactions. Close monitoring will identify any adverse effects.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a healthy woman aged between 65 and 80.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Bone metabolism
Immunoblot on muscle biopsy samples
Maximal oxygen uptake (VO2 max) test
+4 moreSecondary outcome measures
Glucose profile
Hemoglobin A1C
Insulin
+2 moreTrial Design
2Treatment groups
Active Control
Placebo Group
Group I: Nicotinamide RibosideActive Control1 Intervention
NR is a single chemical moiety containing nicotinamide and ribose. The investigational product is a synthetic NR that is nature-identical to naturally-occurring NR, does not induce flushing or pruritus and has no effect on lipid levels.
Group II: PlaceboPlacebo Group1 Intervention
Correspondent placebo, a pill not containing the active component.
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Who is running the clinical trial?
Mayo ClinicLead Sponsor
3,213 Previous Clinical Trials
3,766,963 Total Patients Enrolled
Eduardo N Chini, MDPrincipal InvestigatorMayo Clinic
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My kidney function is severely reduced.I have used sodium fluoride before.I have a musculoskeletal disorder.I cannot or will not give my consent to participate.I have diabetes and use insulin.I have taken bisphosphonates in the last 3 years.I have had gastric bypass surgery.I have been diagnosed with hypopituitarism.I have been treated with denosumab.I have an underactive or overactive parathyroid.I have used oral or inhaled steroids for more than 3 months.I have severe COPD.I have taken estrogen-blocking medication in the last 3 years.I have a condition that prevents my body from absorbing nutrients properly.My diabetes is not well-controlled (HbA1c>8).I have been diagnosed with congestive heart failure.My BMI is either below 18.5 or above 40.I have had a bone fracture in the past year due to osteoporosis.Your blood pressure is very high, with a systolic reading above 180 mmHg or a diastolic reading above 90 mmHg during the initial check-up.I have been diagnosed with acromegaly.I have taken estrogen in the last 3 years.I am a healthy woman aged between 65 and 80.I have been on anticonvulsant therapy in the past year.I have a history of rheumatoid arthritis.I have been diagnosed with liver disease before.I have had moderate to severe kidney disease in the past.I am not taking any medications that are excluded in this trial.I have been diagnosed with Cushing's syndrome.I have taken calcitonin in the last 3 years.I have been diagnosed with cancer.I have been treated with methotrexate before.I am currently taking blood thinners.I have been treated with parathyroid hormone in the last 3 years.I take multivitamins with more than 200 mg of vitamin B3 daily.
Research Study Groups:
This trial has the following groups:- Group 1: Nicotinamide Riboside
- Group 2: Placebo
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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