NR Supplementation for Bone Marrow Transplant Engraftment Improvement
Trial Summary
What is the purpose of this trial?
The purpose of this study is to find a safe and tolerable way to improve engraftment after transplant. Research studies have shown that adding nicotinamide riboside to donor cells has the potential to increase blood stem cell numbers and potentially decrease the time to engraftment. Also, nicotinamide riboside, TRU NIAGEN (the study drug) is a type of vitamin B supplement that the general public can get without a prescription and is well tolerated.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is Nicotinamide Riboside (NR) safe for human use?
How does the NR supplementation treatment differ from other treatments for bone marrow transplant engraftment improvement?
Research Team
Ronald Sobecks, MD
Principal Investigator
Cleveland Clinic, Case Comprehensive Cancer Center
Eligibility Criteria
This trial is for individuals who are eligible for a bone marrow transplant with myeloablative conditioning and have an HLA-identical donor. It's not suitable for pregnant or breastfeeding women, those with uncontrolled illnesses or psychiatric conditions that could affect compliance, or anyone allergic to NR compounds like niacin.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive nicotinamide riboside supplementation to improve engraftment after allogeneic hematopoietic cell transplantation
Engraftment Monitoring
Participants are monitored for engraftment, defined as the process during which transplanted stem cells begin to grow in the bone marrow
Follow-up
Participants are monitored for safety and effectiveness after treatment, including neutrophil and platelet recovery
Treatment Details
Interventions
- Nicotinamide Riboside (NR)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Case Comprehensive Cancer Center
Lead Sponsor