Interrupting Sitting for Sedentary Lifestyle

Overseen By Lindsay Dillon

Age: 18+

Sex: Female

Trial Phase: Academic

Sponsor: University of California, San Diego

Must not be taking: Vasodilators, Immunosuppressants, Corticosteroids, others

Disqualifiers: Type 1 diabetes, Poor glycemic control, Hypertension, Chronic illness, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 5 hours per session

78 Participants Needed

Trial Summary

What is the purpose of this trial?

This protocol "Sedentary Behavior Interrupted: A randomized crossover trial of acute effects on biomarkers of healthy aging in the laboratory (Project 1)" is part of a National Institutes of Aging Program Grant called "Sedentary Time \& Aging Mortality and Physical Function (STAR). The overall purpose of the STAR program to is to better understand how to interrupt sitting time and the consequences for healthy aging in postmenopausal women. This protocol (also referred to Project 1 of the STAR program) is a 3-condition randomized crossover clinical trial of up to 86 postmenopausal women to test whether different interruptions to prolonged sitting improve metabolism.

Eligibility Criteria

This trial is for postmenopausal women over 55 who are generally sedentary, with a BMI of 25-45 kg/m2. They must be medically stable, not involved in other physical activity studies, and able to commit to the study's requirements. Exclusions include those with significant weight changes recently, uncontrolled diabetes or hypertension, certain chronic illnesses like active cancer or HIV/AIDS, smokers, and those on specific medications.

Inclusion Criteria

I sit for 8+ hours, stand up <60 times, and do <20 mins of exercise daily.

Your body mass index (BMI) falls between 25 and 45.

I am medically stable and can stand and perform physical activities.

Exclusion Criteria

Your weight has not changed by more than 5% (either up or down) in the last 3 months.

My blood pressure is not higher than 165/100.

I have type 2 diabetes and use insulin or my blood sugar control is poor.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants undergo a randomized crossover trial to test the effects of different sitting interruption modalities on biomarkers of healthy aging

5 hours per session

Multiple sessions (in-person)

Follow-up

Participants are monitored for any immediate effects post-treatment

1 day

Treatment Details

Interventions

• Frequent sit-to-stands
• Stand More

Trial Overview The trial examines if interrupting sitting time with frequent sit-to-stands or standing more can improve metabolism as part of healthy aging. It's a randomized crossover clinical trial where participants will experience different conditions to compare effects on their health markers.

Participant Groups

Group I: Stand More (Protocol C) Experimental Treatment 1 Intervention

Following a 1-hour sitting run-in period, participants will sit for a 5-hour period including 5 8-minute standing breaks, 1 per hour, and a mid-point bathroom break.

Group II: Frequent Sit-to-Stands (Protocol B) Experimental Treatment 1 Intervention

Following a 1-hour sitting run-in period, participants will sit for a 5-hour period including a 2-min stand every 15 min throughout the 5-hr protocol period and a mid-point bathroom break.

Group III: Control Condition (Protocol A) Active Control 1 Intervention

Following a one-hour sitting run-in period, participants will sit for a 5-hour period including a mid-point bathroom break.

Who Is Running the Clinical Trial?

University of California, San Diego

Lead Sponsor

Trials

1,215

Recruited

1,593,000+