ZyMot Multi Sperm Separation Device (850 ul) for ART

Phase-Based Estimates
1
Effectiveness
1
Safety
NYU Langone Reproductive Specialists of NY, New York, NY
ZyMot Multi Sperm Separation Device (850 ul) - Device
Eligibility
18+
All Sexes
Eligible conditions
ART

Study Summary

This study is evaluating whether a new method of separating sperm cells may improve the success rate of in vitro fertilization.

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Treatment Effectiveness

Study Objectives

This trial is evaluating whether ZyMot Multi Sperm Separation Device (850 ul) will improve 1 primary outcome in patients with ART. Measurement will happen over the course of Culture Day 5 or 6.

Day 5
Percentage of Good Quality Blastocyst Formation

Trial Safety

Trial Design

2 Treatment Groups

Density Gradient Centrifugation
ZyMot Separation

This trial requires 55 total participants across 2 different treatment groups

This trial involves 2 different treatments. ZyMot Multi Sperm Separation Device (850 Ul) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

ZyMot Separation
Device
Treatment
Density Gradient Centrifugation
Other
Control

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: culture day 5 or 6
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly culture day 5 or 6 for reporting.

Closest Location

NYU Langone Reproductive Specialists of NY - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
to participate in a study may be enrolled if they meet the following criteria: In order to participate in a study, a patient must be able to provide informed consent show original
Patient(s) over 18 years of age
The use of ICSI for oocyte insemination is being considered as a possible treatment for infertility show original
An individual must have at least six mature oocytes available at the time of insemination in order to undergo the ICSI procedure. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What causes art?

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Pain, aesthetics, and fear are some common reasons reported for making a request to purchase or display artworks. All these factors have some bearing on how art is perceived and used in society.

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Can art be cured?

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At present there is no evidence in the art profession to suggest that art can be healed or cured, but it remains open to question. There will be much more rigorous research in future to give a definitive answer to this important question for patients and clinicians.

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How many people get art a year in the United States?

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The number of Americans who receive artistic expression through work has remained relatively constant at around 600,000 in the past 15 yr (0.6% annually on average). This small percentage of the public may be a serious concern.

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What are the signs of art?

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Art is often the product of a variety of skills. It can be seen in a wide variety of media from sculptures to paintings to tapestries. Understanding this will help prevent or treat illness.

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What are common treatments for art?

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art and the other visual arts have been popularly used as an outlet for personal pain and self-expression, and art history documents the influence of art on a wide range of people throughout history. There are many types of art from drawing to sculpture to theatre to video to photography and more. In this article, we describe only the common types of art that a modern-day ophthalmologist might encounter.

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What is art?

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Artistic creativity plays a significant role in our lives and has a profound impact on our own well-being and satisfaction. Its contribution can range from the visual and performing arts to self-expression and emotional healing through creating or being inspired by creative works. Art can make an impact on people's lives and well being both for their sake and for the sake of their patients. This is why we believe that, [art therapy] should be included as an option to meet the needs and treatment goals of patients with cancer/cancer related symptoms.\n[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174749/; https://www.ncbi.nlm.nih.

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Who should consider clinical trials for art?

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We think that there are at least 3 groups of patients who may benefit from clinical trials for art. First is patients who have been diagnosed with clinical anxiety disorders, and are experiencing symptoms and distress from the illness. These patients may benefit from therapeutic drugs that target clinical anxiety. Second is patients with clinical depression who are experiencing symptoms and distress from the illness, and require a treatment in the form of clinical trials for art. Finally, patients with clinical depression who are currently being treated with some form of therapy may benefit from an additional form of therapy that is a clinical trial for art. It is important, however, for patients to discuss their options with their clinician.

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What does zymot multi sperm separation device (850 ul) usually treat?

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ZMT(S1) is well described in literature. There was no correlation between number of sperm per tube and time to pregnancy in our case. In the case of spermatoza >150 motile sperm per tube, more time will be needed for pregnancy.

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What is the average age someone gets art?

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In 2017, the average age someone got art was 38.5 years. The most popular medium was oil and watercolour at 39.3% and 38.3% of respondents respectively. The most popular medium by age was acrylic, oil & watercolour at 32.5%. Results from a recent clinical trial show that art is highly recommended for young people as well as mature ages. These statistics in 2016 are a result of Power and are [not in Public Domain]. You can use [Paginy(https://pagin.api.gov/pages/Paginy.

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What are the latest developments in zymot multi sperm separation device (850 ul) for therapeutic use?

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Since the present invention, the method for zymot has been modified, it has been improved by introducing the new device for therapeutic use. The new system of zymot machine has become the first universal multi sperm separation device in a wide range of applications of fertility with the ability to isolate both motile and non-motile sperm from an ejaculate in an efficient manner.

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Is zymot multi sperm separation device (850 ul) typically used in combination with any other treatments?

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Zimulti Foil has been successfully used in combination with the following treatments: Sperm washing only after capacitation and ligation, a postcoital incubation and a sperm preparation solution of 0.02 % quinacrine dihydrochloride and 0.01 % trisodium hexametaphosphate in Phosphate buffered saline. These treatments have been effective for obtaining sperm of excellent quality and, therefore, are well suited for couples with a history of NP when ICSI has to be done in isolation (no assisted reproductive technique is used.) However, Zimulti Foil can also be used in some situations, especially when other treatments are used.

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Have there been other clinical trials involving zymot multi sperm separation device (850 ul)?

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There are very limited data regarding use of zymot in clinic. A few articles have been published, and there have been clinical trials comparing use of Zymot to IUI. I will be addressing this topic with a review, assuming this was a reasonable question from the reader's perspective.

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