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Sperm Sorting for Gender Selection in Infertility Treatment

Led By Gianpiero Palermo, MD, PhD
Research Sponsored by Weill Medical College of Cornell University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up 8 years
Awards & highlights


This trial is testing a new way to pick gender-specific sperm for in vitro fertilization or intrauterine insemination.

Who is the study for?
This trial is for couples undergoing infertility treatments like IVF or insemination who wish to select the gender of their offspring, whether for medical or non-medical reasons. Couples with severe male factor infertility cannot participate.Check my eligibility
What is being tested?
The study tests a method to choose sperm based on desired gender before using them in standard fertility treatments such as in vitro fertilization (IVF) or intrauterine insemination.See study design
What are the potential side effects?
Since the intervention involves standard fertility procedures, potential side effects may include discomfort from sperm collection and typical risks associated with IVF or insemination, like multiple pregnancies.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of embryos of the desired gender in couples
Rate of gender bearing spermatozoa after 4-layer density gradient
Rate of offspring of the desired gender in couples

Trial Design

1Treatment groups
Experimental Treatment
Group I: Sperm sortingExperimental Treatment1 Intervention
Selection of gender specific spermatozoa using a multilayer density gradient

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for infertility include ovulation induction, assisted reproductive technologies (ART) such as in vitro fertilization (IVF), and sperm retrieval techniques. Ovulation induction uses medications like clomiphene citrate or gonadotropins to stimulate the ovaries to produce eggs. ART involves retrieving eggs and sperm, fertilizing them outside the body, and transferring the embryo back into the uterus. Sperm retrieval techniques, such as testicular sperm extraction (TESE), are used when men have low or no sperm in their ejaculate. These treatments are crucial as they address specific causes of infertility, increasing the chances of conception. Gender-specific sperm selection, like density gradient separation, is a method used to select sperm carrying a specific sex chromosome, which can be used in ART to influence the gender of the offspring. This matters for infertility patients as it provides more control over reproductive outcomes and can be particularly important for those with genetic concerns.

Find a Location

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
1,064 Previous Clinical Trials
1,317,186 Total Patients Enrolled
24 Trials studying Infertility
6,633 Patients Enrolled for Infertility
Gianpiero Palermo, MD, PhDPrincipal InvestigatorWeill Medical College of Cornell University
1 Previous Clinical Trials
1,200 Total Patients Enrolled
1 Trials studying Infertility
1,200 Patients Enrolled for Infertility

Media Library

Sperm Sorting (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05500573 — N/A
Infertility Research Study Groups: Sperm sorting
Infertility Clinical Trial 2023: Sperm Sorting Highlights & Side Effects. Trial Name: NCT05500573 — N/A
Sperm Sorting (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05500573 — N/A
Infertility Patient Testimony for trial: Trial Name: NCT05500573 — N/A
~234 spots leftby Dec 2025