This trial is evaluating whether niPGT-A will improve 2 primary outcomes and 9 secondary outcomes in patients with Infertility. Measurement will happen over the course of 7 days at least.
This trial requires 1108 total participants across 2 different treatment groups
This trial involves 2 different treatments. NiPGT-A is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"The clinical presentation of a baby with Down syndrome can differ from that of an individual with trisomy 18. The most common signs of Down syndrome are mild or no learning disabilities and facial features typically associated with autism. There are no specific symptoms associated with trisomy 18." - Anonymous Online Contributor
"Aneuploidy cannot be cured. However, the impact of aneuploidy on development and disease is variable. Some individuals with aneuploidy may have an increased risk of birth defects, mental retardation, and cancer, but others may have an increased risk of developmental delay, hyperactivity, or seizures. Aneuploidy is a risk factor for schizophrenia. The overall impact of aneuploidy may be minimal, or absent altogether." - Anonymous Online Contributor
"The main cause of aneuploidy is non-disjunction during cell division. Other factors that can contribute to aneuploidy include chromosomal abnormalities caused by gene damage during mitosis (as in cases involving genetic syndromes that predispose to cancer) and chromosome loss after DNA replication (as in cases involving chromosomal abnormalities without a specific predisposition to cancer)." - Anonymous Online Contributor
"While there is usually no obvious treatment for aneuploidy, when indicated, treatment is not necessarily harmful. It may be recommended to treat aneuploidy on a case-by-case basis. At present any form of therapy can be harmful to the fetus, and therefore is not recommended. For pregnancies that are known to have aneuploidy, treatment is recommended. For the rest of the patients, further monitoring of the child after childbirth is necessary." - Anonymous Online Contributor
"Aneuploidy is a common cause of miscarriage in the first trimester. More study needs to be carried out to establish the causes and effects of aneuploidy." - Anonymous Online Contributor
"Data from a recent study indicate that more than 3,000 fetuses in the United States are born aneuploid each year and therefore should be identified as fetuses at risk of adverse events. Although aneuploidy is an important cause of prenatal and neonatal deaths and disabilities, this is the first study to demonstrate a significant increase in the number of cases of aneuploidy each year in North America; consequently, there is a growing need for better diagnosis and better strategies for surveillance of patients with aneuploidy. In view of the increasing frequency and seriousness of aneuploidy, efforts need to be made to expand the detection and medical management of fetuses at risk." - Anonymous Online Contributor
"While the age range for individuals is large, the average age for individuals is 35 years. This finding is of more than just limited interest to the medical research community; it is imperative that patients, their families, and the general public have a better understanding of the average age that a patient who is known to be a carrier of aneuploidy will undergo prenatal testing." - Anonymous Online Contributor
"For the first time, aneugenetic and aploidy profiling was carried out by fluorescent gel electrophoresis and karyotyping in a large set of a large family (20 members in total). Results from a recent clinical trial suggest a strong genetic and/or environmental basis for aneuploidy. The analysis of a large number of individuals confirms already known a priori family risks of aneuploidy (17.3% in first-degree relationship), but also reveals new aneugenic families at low familial load. In the future, these data will be valuable in understanding the environmental effects on the reproductive process. They may not be applicable to all pedigrees, however." - Anonymous Online Contributor
"The two genes mentioned were found to be associated with aneuploidy in humans. They appeared to be functionally related, as expression of nipgt-a was detected only in clones containing the extra nipgt-a copy and was not detected in clones containing only one of the two alleles of an additional gene. Considering that aneuploidy in humans is usually diagnosed and characterized through fluorescence in situ hybridization, our findings provide further evidence that the nipgt-a gene is indeed and important for aneuploidy." - Anonymous Online Contributor
"The following associations can contribute to aneuploidy: maternal, paternal or both in the case of the latter. Also, the presence of both gametes with chromosomal loss seems to be associated with a higher frequency, compared with the presence of a single aneuploid gamete, the aneuploidy occurring in the absence of such gametes." - Anonymous Online Contributor
"Gene-based preimplantation genetic tests are safe for women, particularly for women not contemplating ART, although the test information is not available immediately. Clinics should consider offering test information at the time of counselling, and women undergoing ART should be informed of the test information." - Anonymous Online Contributor
"This is the first reported use of a new anti-GATA4-based clinical approach to the treatment of patients with aneuploidy. Although there was one patient with persistent disease remission, further research is warranted." - Anonymous Online Contributor