Surgery for Tethered Cord Syndrome

Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Weill Cornell Medicine, New York, NYTethered Cord Syndrome+3 MoreRelease of filum terminale - Procedure
Eligibility
2 - 80
All Sexes
What conditions do you have?
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Study Summary

This trial is testing whether cutting a strand of tissue at the end of the spinal cord is a more effective treatment forsymptoms than current medical management, and whether the risks are outweighed by the potential benefits.

Eligible Conditions
  • Tethered Cord Syndrome
  • Spina Bifida Occulta
  • Occult Spina Bifida

Treatment Effectiveness

Study Objectives

1 Primary · 5 Secondary · Reporting Duration: 1 year

1 year
Number of patients who cross over
Percent of patients with a decrease in anticholinergic medications at 1 year post-surgery
Baseline, 1 year
Change in fecal incontinence score
Change in symptoms related to tethered cord, as measured by the OCCULT Scale
Change in urologic incontinence score
Intraoperative
Number of intra-operative findings that are discordant with MRI interpretations

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Surgery
1 of 2
Observation
1 of 2

Active Control

20 Total Participants · 2 Treatment Groups

Primary Treatment: Surgery · No Placebo Group · Phase 2

Surgery
Procedure
ActiveComparator Group · 1 Intervention: Release of filum terminale · Intervention Types: Procedure
ObservationNoIntervention Group · 1 Intervention: Observation · Intervention Types:

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

Weill Medical College of Cornell UniversityLead Sponsor
997 Previous Clinical Trials
1,341,935 Total Patients Enrolled
Jeffrey Greenfield, MD, PhDPrincipal InvestigatorWeill Medical College of Cornell University

Eligibility Criteria

Age 2 - 80 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have been experiencing symptoms that have not improved with medical treatment for at least one year.

Frequently Asked Questions

Is the study seeking volunteers who are aged 60 and above?

"Patients aged 2 to 80 are eligible for recruitment into this trial, in accordance with the stated criteria." - Anonymous Online Contributor

Unverified Answer

How many participants are involved in this clinical experiment?

"Affirmative, according to clinicaltrials.gov this study is actively searching for volunteers enrolled in it. The trial was initially posted on May 19th 2022 and the latest update took place July 15th of the same year. 1 site will be recruiting a total of 20 individuals into the experiment." - Anonymous Online Contributor

Unverified Answer

What potential hazards should patients be aware of before undergoing a surgical procedure?

"There is limited evidence on the safety of surgery, so it got a score of 2." - Anonymous Online Contributor

Unverified Answer

Who is eligible to join this medical research?

"Those hoping to take part in this clinical trial should have tethered cord syndrome and be within the ages of 2 and 80. A total of 20 participants are required for this study." - Anonymous Online Contributor

Unverified Answer

Are there any vacancies for volunteers in this research endeavor?

"Correct. According to clinicaltrials.gov, this trial is currently recruiting participants, which began on the 19th of May 2022 and was last edited 15 July 2022. This study seeks 20 patients from a single site location." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.