Treatment for Heat Stroke

Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Heat Stroke+3 More
Eligibility
18 - 49
All Sexes
What conditions do you have?
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Study Summary

In 2012, it was estimated that nearly 1 in 4 Canadians suffer from allergic rhinitis. To add, 78% of individuals working in predisposing environments are predicted to develop occupational rhinitis. Currently, the most popular treatment for rhinitis is antihistamine medication such as diphenhydramine, a first-generation antihistamine sold commercially as Benadryl®. Due it its anticholinergic effects, diphenhydramine has been suggested to impair the whole body sweating response during heat stress, potentially leaving consumers at an increased risk of heat-related illness. This randomized control trial approved by Health Canada will investigate whether ingesting extra strength diphenhydramine (50mg) will alter whole-body sweat losses during 60 minutes of exercise.

Eligible Conditions
  • Heat Stroke
  • Allergy (or Hay Fever)
  • Hyperhidrosis
  • Anticholinergic Syndrome

Treatment Effectiveness

Effectiveness Progress

3 of 3
This is further along than 93% of similar trials

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: Measured during both placebo and diphenhydramine intervention trials trials, separated by no more than 28 days

Day 28
Change in rectal temperature
Sweating

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Trial Design

0 Treatment Group

20 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · Has Placebo Group · Phase 4

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: measured during both placebo and diphenhydramine intervention trials trials, separated by no more than 28 days

Who is running the clinical trial?

Lakehead UniversityLead Sponsor
18 Previous Clinical Trials
2,649 Total Patients Enrolled
Nicholas Ravanelli, PhDPrincipal InvestigatorLakehead University

Eligibility Criteria

Age 18 - 49 · All Participants · 4 Total Inclusion Criteria

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