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Heat Stress Recommendations for Kidney Dysfunction (Aim1 Trial)
N/A
Waitlist Available
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, up to 20 weeks
Awards & highlights
Aim1 Trial Summary
This trial will test if the heat stress recommendations protect workers from kidney dysfunction.
Eligible Conditions
- Hyperthermia
- Heat Exhaustion
- Kidney Injury
- Dehydration
- Kidney Dysfunction
- Heat Stroke
Aim1 Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ through study completion, up to 20 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, up to 20 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Peak urinary [IGFBP7•TIMP-2]
Secondary outcome measures
Renal artery blood velocity
Segmental artery blood velocity
Urinary IGFBP7
+4 moreOther outcome measures
Blood and plasma volume
Blood pressure
Core body temperature
+14 moreAim1 Trial Design
2Treatment groups
Experimental Treatment
Group I: Fixed work-to-rest ratioExperimental Treatment3 Interventions
This study will systematically examine the NIOSH recommendations on changes in kidney function when the work-to-rest ratio is fixed at 30 min per hour (the most commonly prescribed work-to-rest ratio), but the rate of metabolic heat production and environmental heat stress differs (Figure 2). As described in Study 1, the appropriate rate of metabolic heat production will be elicited by having participants walk on a treadmill at 3 mph and the grade will be adjusted accordingly.
Group II: Fixed Work RateExperimental Treatment5 Interventions
Participants will walk on a treadmill at 3 mph and the grade will be adjusted to elicit 430 W of metabolic heat production (the most common work intensity). This study will systematically examine the NIOSH recommendations for prescribing work-to-rest ratios with increasing environmental heat stress (defined as Wet Bulb Globe Temperature, WBGT) at this fixed rate of metabolic heat production on kidney function.
Find a Location
Who is running the clinical trial?
State University of New York at BuffaloOTHER
246 Previous Clinical Trials
49,450 Total Patients Enrolled
8 Trials studying Hyperthermia
116 Patients Enrolled for Hyperthermia
Indiana UniversityLead Sponsor
980 Previous Clinical Trials
983,123 Total Patients Enrolled
1 Trials studying Hyperthermia
18 Patients Enrolled for Hyperthermia
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You take medication that can affect your body's ability to regulate temperature or balance fluids.You currently have or have had kidney, heart, or immune system problems, or have had surgery on your digestive system.You are taking medications that limit how your body responds to exercise, like beta blockers.Both men and women can participate.You are very active and engage in physical activities that burn a lot of energy.Your body mass index (BMI) is 35.0 or lower.Your body weight is very high compared to your height.You have been using tobacco or electronic cigarettes regularly within the past 2 years.
Research Study Groups:
This trial has the following groups:- Group 1: Fixed Work Rate
- Group 2: Fixed work-to-rest ratio
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any open slots left for participants in this experiment?
"Affirmative. According to data stored on clinicaltrials.gov, this medical trial commenced recruitment of participants on March 1st 2021 and is still ongoing as of October 17th 2022. The research team aims to enroll 40 individuals at a single site."
Answered by AI
How many participants has this research project attracted?
"Yes, according to the information provided on clinicaltrials.gov, this research is in the process of enrolling participants. The study was first established on March 1st 2021 and recently modified on October 17th 2022. It seeks 40 people across a single site for its testing phase."
Answered by AI
Is there a way to become involved in the experimental program?
"To meet the eligibility criteria of this trial, volunteers must suffer from dehydration and be between 18-44 years old. This research endeavour is seeking 40 individuals in total."
Answered by AI
Is the eligibility for this medical experiment restricted to individuals over a certain age?
"This particular medical trial is only suitable for participants aged between 18 and 44 years old. However, there are 32 other studies available to under-18s and 88 trials specifically designed for octogenarians or older."
Answered by AI
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