12 Participants Needed

Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain

TW
Overseen ByThomas W Service, MSc
Age: 18 - 65
Sex: Male
Trial Phase: Academic
Sponsor: University of Victoria
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial requires that you stop taking NSAIDs, steroid drugs, and any medication that could have adverse reactions with desloratadine. You also need to avoid antibiotics for 14 days before the trial.

What data supports the effectiveness of the drug Desloratadine?

Desloratadine is effective in treating seasonal allergic rhinitis (hay fever), perennial allergic rhinitis, and chronic idiopathic urticaria (hives) by reducing symptoms like nasal congestion and improving quality of life. It works as a nonsedating antihistamine, meaning it blocks the effects of histamine (a chemical in the body that causes allergy symptoms) without causing drowsiness.12345

What is the purpose of this trial?

This trial investigates whether desloratadine can reduce inflammation in firefighters exposed to high heat. Firefighters often face extreme temperatures that can cause harmful inflammation. Desloratadine, typically used for allergies, may help by stabilizing certain cells in the body. Desloratadine also has anti-inflammatory activity.

Research Team

LS

Lynneth Stuart-Hill, PhD

Principal Investigator

University of Victoria

Eligibility Criteria

Inclusion Criteria

Biological males aged 19-50
Demonstrated willingness to participate in the study and adhere to procedures by signing a written informed consent
Successful Physical Activity Readiness Questionnaire (PAR-Q)
See 4 more

Exclusion Criteria

Biological females
VO2Max below 35 mL/kg/min
You are allergic to medications that block H1 histamine receptors.
See 10 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive 10mg desloratadine before and 24 hours after exertional heat strain to assess inflammatory response

1 week
3 visits (in-person)

Follow-up

Participants are monitored for changes in inflammatory markers and other physiological responses after treatment

1 week
3 visits (in-person)

Treatment Details

Interventions

  • Desloratadine
  • No Intervention
  • Placebo
Participant Groups
3Treatment groups
Experimental Treatment
Group I: No InterventionExperimental Treatment1 Intervention
No intervention: neither drug nor placebo
Group II: Inert PlaceboExperimental Treatment1 Intervention
Placebo 10mg compounded to oral pill
Group III: DesloratadineExperimental Treatment1 Intervention
Desloratadine (Aerius) 10mg compounded to oral pill

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Victoria

Lead Sponsor

Trials
59
Recruited
12,000+

References

Desloratadine: an update of its efficacy in the management of allergic disorders. [2018]
A pharmacokinetic profile of desloratadine in healthy adults, including elderly. [2018]
Desloratadine demonstrates dose proportionality in healthy adults after single doses. [2018]
The pharmacologic profile of desloratadine: a review. [2019]
Pharmacology and clinical efficacy of desloratadine as an anti-allergic and anti-inflammatory drug. [2019]
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