Role of Desloratadine in Reducing Inflammation From Occupational Heat Strain
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking NSAIDs, steroid drugs, and any medication that could have adverse reactions with desloratadine. You also need to avoid antibiotics for 14 days before the trial.
What data supports the effectiveness of the drug Desloratadine?
Desloratadine is effective in treating seasonal allergic rhinitis (hay fever), perennial allergic rhinitis, and chronic idiopathic urticaria (hives) by reducing symptoms like nasal congestion and improving quality of life. It works as a nonsedating antihistamine, meaning it blocks the effects of histamine (a chemical in the body that causes allergy symptoms) without causing drowsiness.12345
What is the purpose of this trial?
This trial investigates whether desloratadine can reduce inflammation in firefighters exposed to high heat. Firefighters often face extreme temperatures that can cause harmful inflammation. Desloratadine, typically used for allergies, may help by stabilizing certain cells in the body. Desloratadine also has anti-inflammatory activity.
Research Team
Lynneth Stuart-Hill, PhD
Principal Investigator
University of Victoria
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 10mg desloratadine before and 24 hours after exertional heat strain to assess inflammatory response
Follow-up
Participants are monitored for changes in inflammatory markers and other physiological responses after treatment
Treatment Details
Interventions
- Desloratadine
- No Intervention
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Victoria
Lead Sponsor