Desloratadine for Inflammation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether the allergy medication desloratadine can reduce inflammation caused by heat stress in firefighters wearing protective gear. Researchers compare this medication to a placebo (a pill with no active drug) and a group with no treatment to determine its effectiveness in managing heat-related inflammation. The study seeks male firefighters in good health, not currently using certain medications, and who can swallow a special capsule to measure body temperature. This trial may suit those who frequently work in high-heat environments and are interested in new ways to manage heat strain. As an unphased trial, it offers participants the chance to contribute to innovative research that could improve heat strain management in high-risk professions.
Will I have to stop taking my current medications?
The trial requires that you stop taking NSAIDs, steroid drugs, and any medication that could have adverse reactions with desloratadine. You also need to avoid antibiotics for 14 days before the trial.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that desloratadine is generally safe for people. Commonly used for allergies, this medication doesn't present any special safety concerns. Studies have found that even with long-term use, desloratadine doesn't cause harmful effects, suggesting it is safe for most individuals. Its approval by health authorities for other uses further supports confidence in its safety. However, like any medication, some individuals might experience mild side effects. Consulting a healthcare provider before joining a trial is always advisable.12345
Why are researchers excited about this trial?
Most treatments for inflammation from occupational heat strain focus on cooling techniques or hydration strategies. However, desloratadine, commonly known as Aerius, is unique because it's an antihistamine that may reduce inflammation through a different pathway. Unlike traditional approaches, desloratadine could potentially lower inflammation by blocking histamine receptors, which play a role in the body's inflammatory response. Researchers are excited about exploring this because it offers a novel way to address heat-related inflammation, possibly leading to more effective management strategies for those exposed to high temperatures at work.
What evidence suggests that desloratadine could be effective for reducing inflammatory responses to heat stress in firefighters?
Research has shown that desloratadine, which participants in this trial may receive, helps reduce symptoms of long-term nasal allergies, known as perennial allergic rhinitis. In various studies, desloratadine significantly lessened symptoms like stuffy nose and itching. It worked quickly and remained effective for several weeks. Although these studies focused on allergies, desloratadine's ability to reduce swelling might also aid other inflammation-related issues, such as heat stress. However, specific data on desloratadine's effectiveness for heat-related inflammation is not yet available.46789
Who Is on the Research Team?
Lynneth Stuart-Hill, PhD
Principal Investigator
University of Victoria
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive 10mg desloratadine before and 24 hours after exertional heat strain to assess inflammatory response
Follow-up
Participants are monitored for changes in inflammatory markers and other physiological responses after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Desloratadine
- No Intervention
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Victoria
Lead Sponsor