60 Participants Needed

Heat Therapy for Alzheimer's Prevention

(FIGHT-AD Trial)

JM
PG
JM
Overseen ByJill Morris, PhD
Age: 65+
Sex: Any
Trial Phase: Academic
Sponsor: University of Kansas Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The investigators will determine if heat therapy can improve blood (Aim 1) and brain (Aim 2) glucose metabolism in cognitively healthy older adults (65+) who are at risk for AD. The investigators will also examine the degree to which changes in blood and brain glucose metabolism track together and explore several additional potential mechanisms that are critical to understanding the brain benefits of heat therapy (Aim 3). These aims will provide a comprehensive understanding of the impact of heat therapy on whole body metabolic function and brain health.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it requires that your medication doses have been stable for more than one month before joining.

How does heat therapy differ from other treatments for Alzheimer's prevention?

Heat therapy for Alzheimer's prevention is unique because it focuses on using heat to potentially improve blood flow and promote the clearance of harmful proteins in the brain, unlike other treatments that often involve medications or lifestyle changes like diet and exercise. This approach is novel as it targets the vascular system to aid in the removal of amyloid-beta, a protein linked to Alzheimer's, which is not a common focus in existing treatments.12345

Research Team

JM

Jill Morris, PhD

Principal Investigator

University of Kansas Medical Center

Eligibility Criteria

This trial is for people aged 65 or older who are cognitively healthy but at risk for Alzheimer's Disease. They should have stable medication doses, be post-menopausal, and may have a history of metabolic issues like pre-diabetes. Those with Type 1 Diabetes, high cardiovascular risk without clearance, certain chronic diseases, heat intolerance conditions or recent heart problems cannot join.

Inclusion Criteria

I have a history of or currently have a metabolic condition like pre-diabetes or Type 2 Diabetes.
I have gone through menopause.
I am 65 years old or older.
See 2 more

Exclusion Criteria

I have not had a heart attack or heart disease symptoms in the last 2 years.
I do not have severe depression, use psychoactive drugs, or have major hearing or vision problems.
I cannot have an MRI or have a pacemaker that needs clearance.
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 10 weeks of heat therapy to improve blood and brain glucose metabolism

10 weeks
3 visits per week (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Water Immersion Heat Therapy
Trial Overview The study tests if water immersion heat therapy can improve blood and brain glucose metabolism in older adults to prevent Alzheimer's Disease. It will also explore how these changes might benefit overall brain health and body metabolism.
Participant Groups
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Heat therapy GroupExperimental Treatment1 Intervention
40.5°C water
Group II: Thermoneutral Control GroupPlacebo Group1 Intervention
36°C water

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Kansas Medical Center

Lead Sponsor

Trials
527
Recruited
181,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

References

Development of a Multicomponent Intervention to Prevent Alzheimer's Disease. [2020]
Beneficial Effects of an Integrated Psychostimulation Program in Patients with Alzheimer's Disease. [2018]
Novel Nutraceutical Compounds in Alzheimer Prevention. [2022]
Therapies for Prevention and Treatment of Alzheimer's Disease. [2022]
Recruitment methods for United States Alzheimer disease prevention trials. [2021]
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