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Dendritic Cell/Tumor Fusion Vaccine for Ovarian Cancer

Massachusetts General Hospital, Boston, MA
Ovarian Cancer+2 More ConditionsDendritic Cell/Tumor Fusion Vaccine - Biological
Eligibility
18+
Female
What conditions do you have?
Select

Study Summary

This trial is testing a new cancer vaccine made from a person's own dendritic cells. Dendritic cells are powerful immune cells that help the body fight infections. The vaccine will be given with laboratory made agents GM-CSF and imiquimod. Researchers want to see if the vaccine is safe and if it has any effect on the person's cancer.

Eligible Conditions
  • Ovarian Cancer
  • Primary Peritoneal Cancer

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

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Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 2 years

2 years
To assess clinical response to vaccination with DC/tumor fusion when given with GM-CSF and imiquimod.
To assess toxicity associated with vaccination with DC/tumor fusion when given with GM-CSF and imiquimod.
To correlate immunologic response following vaccination with measures of patient cellular immune function and phenotypic characteristics of the vaccine preparation.
To determine if cellular immunity is induced by serial vaccination with DC/tumor fusion cells, when given with GM-CSF alone, or the combination of GM-CSF and imiquimod in this patient population.

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

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1
MRI
1
Datopotamab deruxtecan
1
Venetoclax

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

2 Treatment Groups

Group 2
1 of 2
Group 1
1 of 2

Experimental Treatment

23 Total Participants · 2 Treatment Groups

Primary Treatment: Dendritic Cell/Tumor Fusion Vaccine · No Placebo Group · Phase 2

Group 2Experimental Group · 3 Interventions: Dendritic Cell/Tumor Fusion Vaccine, GM-CSF, imiquimod · Intervention Types: Biological, Drug, Drug
Group 1Experimental Group · 2 Interventions: Dendritic Cell/Tumor Fusion Vaccine, GM-CSF · Intervention Types: Biological, Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
GM-CSF
2014
Completed Phase 4
~1340
Imiquimod
FDA approved

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 2 years

Who is running the clinical trial?

Beth Israel Deaconess Medical CenterLead Sponsor
790 Previous Clinical Trials
849,492 Total Patients Enrolled
12 Trials studying Ovarian Cancer
473 Patients Enrolled for Ovarian Cancer
Dana-Farber Cancer InstituteOTHER
1,029 Previous Clinical Trials
755,793 Total Patients Enrolled
38 Trials studying Ovarian Cancer
4,277 Patients Enrolled for Ovarian Cancer
Massachusetts General HospitalOTHER
2,778 Previous Clinical Trials
31,224,660 Total Patients Enrolled
27 Trials studying Ovarian Cancer
4,027 Patients Enrolled for Ovarian Cancer
Brigham and Women's HospitalOTHER
1,517 Previous Clinical Trials
11,304,036 Total Patients Enrolled
12 Trials studying Ovarian Cancer
352 Patients Enrolled for Ovarian Cancer
National Cancer Institute (NCI)NIH
13,272 Previous Clinical Trials
41,230,705 Total Patients Enrolled
285 Trials studying Ovarian Cancer
73,843 Patients Enrolled for Ovarian Cancer
David Avigan, MDPrincipal InvestigatorBeth Israel Deaconess Medical Center
14 Previous Clinical Trials
436 Total Patients Enrolled
1 Trials studying Ovarian Cancer
100 Patients Enrolled for Ovarian Cancer

Eligibility Criteria

Age 18+ · Female Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a small amount of disease that does not need more chemotherapy before starting vaccination, and you do not have any symptoms.
References

Frequently Asked Questions

How many individuals are currently partaking in this medical research?

"No longer seeking participants, this research was first posted on August 1st 2008 and last edited on January 25th 2022. If you are exploring other medical studies, presently there 694 active trials accepting patients with fallopian tubes cancer and 21 clinical investigations looking for volunteers to receive a Dendritic Cell/Tumor Fusion Vaccine." - Anonymous Online Contributor

Unverified Answer

What potential risks do patients face when utilizing Dendritic Cell/Tumor Fusion Vaccine?

"We have assigned Dendritic Cell/Tumor Fusion Vaccine a score of 2, as the available evidence suggests it is safe but efficacy data has yet to be produced." - Anonymous Online Contributor

Unverified Answer

Have any other investigations explored the efficacy of Dendritic Cell/Tumor Fusion Vaccine?

"Presently, 21 clinical trials for Dendritic Cell/Tumor Fusion Vaccine are taking place. 5 of these investigations have progressed to the Phase 3 stage. Locations offering this therapy span 84 different sites, with most being located in Houston, Texas." - Anonymous Online Contributor

Unverified Answer

What maladies can be remedied with the Dendritic Cell/Tumor Fusion Vaccine?

"Dendritic Cell/Tumor Fusion Vaccine is effective at treating scalp structure, condylomata acuminata, and facial lesions." - Anonymous Online Contributor

Unverified Answer

Is it possible for new participants to join this clinical trial?

"This medical trial is no longer accepting new participants. It was first posted on August 1st, 2008 and the most recent update to its information occurred on January 25th, 2022. If searching for other studies, 694 clinical trials are actively looking for patients with fallopian tubes cancer while 21 of them seek persons interested in joining a Dendritic Cell/Tumor Fusion Vaccine study." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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