← Back to Search

Behavioural Intervention

CBOT + TAU for Opioid Use Disorder (CBOT-OUD Trial)

Phase 2
Waitlist Available
Led By Marc Fishman, MD
Research Sponsored by Evon Medics LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12 to week 13
Awards & highlights

Summary

This trial will establish the effectiveness of a brain stimulation system in reducing symptoms of opioid withdrawal and reducing negative affect in people with OUDs.

Eligible Conditions
  • Opioid Use Disorder
  • Withdrawal
  • Craving
  • Negative Affect

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12 to week 13
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 12 to week 13 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
6-month buprenorphine maintenance treatment (BMT) retention
Change from Screening in Opioid Craving Scale (OCS) at Week 12 severity rating measures over 1 month
Change from Screening in Opioid Craving Scale (OCS) at Week 24 severity rating measures over 1 month
+3 more
Secondary outcome measures
Opioid Relapse
Post-Intervention changes in OCS from Week 12 to Week 13
Post-Intervention changes in PANAS negative affect from Week 12 at Week 13
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CBOT + TAUExperimental Treatment1 Intervention
CBOT consists of 40 cycles of olfactory stimulation and OFC training tasks, lasting ~45 minutes, once daily over 3 months. Treatment-as-usual (TAU) is standard dosing of buprenorphine (BUP) to a median dose of 24 mg (range 16-32 mg).
Group II: Sham + TAUPlacebo Group1 Intervention
Sham is a CBOT device that uses artificially-scented compressed room air instead of olfactory stimulants and has no OFC cognitive tasks. Similar to the CBOT, sham will be used daily for 45 minutes. TAU is standard dosing of buprenorphine (BUP) to a median dose of 24 mg (range 16-32 mg).

Find a Location

Who is running the clinical trial?

Howard UniversityOTHER
42 Previous Clinical Trials
14,799 Total Patients Enrolled
Family and Medical Counseling Service, IncUNKNOWN
1 Previous Clinical Trials
200 Total Patients Enrolled
Maryland Treatment Centers @ ARTCUNKNOWN
~44 spots leftby Jul 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top