Study Summary
This trial will assess if a nerve block can help reduce symptoms of long COVID.
Eligible Conditions
- Dysautonomia
- Dysautonomia Orthostatic Hypotension Syndrome
- Post-COVID Syndrome
- Long COVID
- COVID-19 Recurrence
- COVID-19
- Post-Acute COVID-19 Syndrome
- Post-Acute COVID-19 Infection
- Long COVID Syndrome
Treatment Effectiveness
Phase-Based Effectiveness
Phase 1
Study Objectives
8 Primary · 1 Secondary · Reporting Duration: 1 month
1 month
Ability to participate in social roles and activities status
Anxiety
Autonomic Symptoms: COMPASS-31 Score
Depression
Fatigue
Pain interference
Patient-Reported Outcomes: PROMIS-29 Score
Physical function
Sleep disturbance
Trial Safety
Phase-Based Safety
Awards & Highlights
No Placebo Group
All patients enrolled in this trial will receive the new treatment.
Trial Design
1 Treatment Group
Active
1 of 1
Experimental Treatment
20 Total Participants · 1 Treatment Group
Primary Treatment: Active · No Placebo Group · Phase 1
Active
Drug
Experimental Group · 1 Intervention: stellate ganglion block with 0.5% bupivacaine · Intervention Types: DrugTrial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 month
Who is running the clinical trial?
Megan NicklayLead Sponsor
Jonathann Kuo, MDLead Sponsor
Eligibility Criteria
Age 18 - 100 · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:You have symptoms of COVID-19 that last for at least four weeks.
References
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Frequently Asked Questions
Has the Active compound been verified by the FDA?
"Since this is a preliminary phase 1 trial, the safety of Active was estimated to be at level one due to limited data on their efficacy and security." - Anonymous Online Contributor
Unverified Answer
Are there any unfilled slots available in this research project?
"Affirmative. Per clinicaltrials.gov, this research initiative is actively accepting new participants. It was initially launched on December 1st 2022 and most recently amended on the same date, with a target of 20 patients at one single medical centre." - Anonymous Online Contributor
Unverified Answer
Do I satisfy the qualifications to enroll in this clinical experiment?
"This clinical trial seeks 20 individuals, ranging between 18 to 100 years of age, who are suffering from dysautonomia. Qualifying patients must have had a confirmed COVID-19 diagnosis by RT-PCR or equivalent testing and display lingering symptoms four weeks after the start of the infection. The COMPASS-31 is used to quantify autonomic symptom domains such as Orthostatic Intolerance and Vasomotor Alterations while PROMIS-29 measures patient reported pain interference or intensity." - Anonymous Online Contributor
Unverified Answer
Does this research permit elderly participants?
"The most recent review of the inclusion criteria specifies that patients must fall between 18-100 years old in order to participate. Separately, there are 947 separate clinical trials designed for minors and 3088 specifically tailored towards seniors." - Anonymous Online Contributor
Unverified Answer