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Alirocumab for Sepsis (PALMS Trial)
PALMS Trial Summary
This trial will test whether the drug alirocumab can reduce inflammation caused by an infection that has caused low blood pressure or difficulty breathing.
PALMS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPALMS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2017 Phase 3 trial • 233 Patients • NCT02023879PALMS Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
What is the prime objective of this trial?
"This medical trial will assess Bacterial endotoxin level over a period of 120 hours as its primary outcome. Secondary measurements include Interleukin-1 beta (IL-1), Interleukin-10 (IL-10) and Tumor necrosis factor - alpha (TNF-alpha). Elevated levels of these proinflammatory cytokines are associated with worse outcomes in patients suffering from sepsis."
How hazardous is Alirocumab for those in the trial?
"Taking into account the limited information available, Alirocumab was given a score of 1 for safety due to it being in its first stage of clinical research."
Can I register for participation in this clinical experiment?
"This medical study is enrolling 50 pyemia patients aged between 18 and 90. To meet the criteria, participants must be using vasopressor agents to maintain a mean arterial pressure of 65 mm Hg, have acute hypoxemic respiratory failure necessitating intubation or positive pressure ventilation, require ICU admission, and evidence suspected infection as evidenced by blood cultures and antimicrobial agent administration."
Is there currently a recruitment phase for this clinical experiment?
"According to the clinicaltrials.gov database, this medical trial is not currently enrolling patients. The experiment was initially made available on September 1st 2022 and has been amended as recently as July 19th 2022. Nevertheless, there are 169 other trials that are still actively recruiting participants at present."
Is this research study open to individuals over 45 years of age?
"The qualifications for this clinical study state that potential participants must be 18-90 years old. Separately, there are 34 trials available to minors and 144 studies approved for seniors."
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