Calcium Fructoborate for Joint Discomfort

Overseen By Jennifer L Robinson, Ph.D.

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Auburn University

Must not be taking: Antibiotics, NSAIDs, Pain relievers

Disqualifiers: Diabetes, Rheumatoid arthritis, Cardiovascular, others

Compensation: Varies

Number of Visits: 7

Duration: 12 weeks

300 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial tests a natural supplement called calcium fructoborate (CFB) to see if it can reduce joint pain in adults. The supplement may help by reducing inflammation in the body. Participants will take the supplement daily for a few months to measure changes in their joint discomfort and overall well-being. Calcium fructoborate (CFB) is a dietary supplement used for managing joint discomfort, leveraging the benefits of organic boron-containing molecules.

Eligibility Criteria

This trial is for people aged 40-65 with knee osteoarthritis and chronic knee pain, who haven't taken antibiotics or joint discomfort drugs recently. Participants need basic computer skills, a smartphone, and reliable internet to join the virtual study but can't have certain health conditions like cardiovascular diseases or diabetes.

Inclusion Criteria

I have had knee pain for more than 3 months.

You should have basic computer skills.

I haven't taken NSAIDs or pain relievers for 2 weeks and can avoid them during the study.

Exclusion Criteria

I have an ongoing infection or inflammation.

I have been prescribed medication for joint pain or osteoarthritis in the last 3 months.

I have diabetes or another metabolic disorder.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either 216mg CFB or placebo daily for 90 days. Check-in questionnaires are administered on days 1, 5, 14, 21, 28, 60, and 90.

12 weeks

7 virtual check-ins

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Calcium Fructoborate
• Placebo

Trial Overview The study tests if Calcium Fructoborate (CFB), a dietary supplement, can relieve joint discomfort over 90 days compared to a placebo. Participants will be randomly assigned to take either CFB or an inactive substance daily in this virtually conducted trial.

Participant Groups

Group I: Calcium Fructoborate Active Control 1 Intervention

Calcium Fructoborate (CFB), is a proprietary, safe generally-recognized-as-safe (GRAS) supplement. The only content of the supplement is CFB - there are no excipients, binders, or flow agents, nor are there any other materials. 216mg of CFB will be administered daily for 90 days.

Group II: Placebo Placebo Group 1 Intervention

The placebo will be a simple microcellulose, which is generally-recognized-as-safe (GRAS) and commonly used in food products.

Who Is Running the Clinical Trial?

Auburn University

Lead Sponsor

Trials

81

Recruited

14,600+