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Vasodilator

Inhaled Nitric Oxide (iNO) for Liver Transplant

Phase 2
Waitlist Available
Led By Michael A Ramsay, MD
Research Sponsored by Baylor Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Liver Transplant
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours to 1 month
Awards & highlights

Study Summary

This study is being done to determine if patients receiving (iNO) will have increased liver function and less damage from IR than patients who do not receive (iNO).

Eligible Conditions
  • Liver Transplant

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours to 1 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours to 1 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Evaluate the role of iNO in early ischemia reperfusion injury in marginal liver grafts during human orthotopic liver or liver/kidney transplantation.
Secondary outcome measures
iNO group will show accelerated restoration of liver allograft function following liver transplantation and this may translate to better clinical outcomes. Marginal grafts may function better in the treated group

Side effects data

From 2014 Phase 2 trial • 124 Patients • NCT00955487
22%
Sepsis
8%
Necrotizing enterocolitis
5%
Threshold ROP
5%
Symptomatic PDA
3%
Severe ICH
100%
80%
60%
40%
20%
0%
Study treatment Arm
Inhaled Nitric Oxide (iNO)
Placebo (Nitrogen)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Placebo and StudyExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Inhaled Nitric Oxide (iNO)
2007
Completed Phase 2
~130

Find a Location

Who is running the clinical trial?

Baylor Research InstituteLead Sponsor
200 Previous Clinical Trials
203,224 Total Patients Enrolled
MallinckrodtIndustry Sponsor
201 Previous Clinical Trials
16,226 Total Patients Enrolled
Michael A Ramsay, MDPrincipal InvestigatorBaylor Health Care System

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts
2010. "Trial of Inhaled Nitric Oxide (iNO) on Ischemia / Reperfusion Injury During Orthotopic Liver Transplantation With Marginal Grafts". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01172691.
All > Liver Transplant
~0 spots leftby Apr 2025
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